News Column

New Dicarboxylic Acids Findings from S.V. Kamzolova and Co-Researchers Described

June 4, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Dicarboxylic Acids are discussed in a new report. According to news originating from Moscow Region, Russia, by NewsRx correspondents, research stated, "The process of succinic acid (SA) production represents the combination of microbial synthesis of alpha-ketoglutaric acid from rapeseed oil by yeast Yarrowia lipolytica VKM Y-2412 and subsequent decarboxylation of alpha-ketoglutaric acid by hydrogen peroxide to SA that leads to the production of 69.0 g l(-1) of SA and 1.36 g l(-1) of acetic acid. SA was isolated from the culture broth filtrate in a crystalline form."

Our news journalists obtained a quote from the research, "The SA recovery from the culture filtrate has certain difficulties due to the presence of residual triglycerides of rapeseed oil. The effect of different methods of the culture filtrate treatment and various sorption materials on the coagulation of triglycerides was studied, and as a result, the precipitation of residual triglycerides by acetone was chosen. The subsequent isolation procedures involved the decomposition of H2O2 in the filtrate followed by filtrate bleaching and acidification with a mineral acid, evaporation of filtrate, and SA extraction with ethanol from the residue."

According to the news editors, the research concluded: "The purity of crystalline SA isolated from the culture broth filtrate achieved 97.6-100 %. The product yield varied from 62.6 to 71.6 % depending on the acidity of the supernatant."

For more information on this research see: The peculiarities of succinic acid production from rapeseed oil by Yarrowia lipolytica yeast. Applied Microbiology and Biotechnology, 2014;98(9):4149-4157. Applied Microbiology and Biotechnology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Applied Microbiology and Biotechnology -

The news correspondents report that additional information may be obtained from S.V. Kamzolova, Pushchino State Inst Nat Sci, Pushchino 142290, Moscow Region, Russia. Additional authors for this research include N.G. Vinokurova, E.G. Dedyukhina, V.A. Samoilenko, J.N. Lunina, A.A. Mironov, R.K. Allayarov and I.G. Morgunov (see also Dicarboxylic Acids).

Keywords for this news article include: Russia, Eurasia, Moscow Region, Succinic Acids, Dicarboxylic Acids

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Source: Biotech Week

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