By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting originating from Chongqing, People's Republic of China, by NewsRx correspondents, research stated, "Liver cancer is one of the top six leading causes of cancer-related death. Radiofrequency ablation (RFA) is an important means of treating liver cancer."
Our news editors obtained a quote from the research from Third Military Medical University, "Residual cancer after RFA is the most frequent cause of recurrence in cases of liver cancer. The main difference between residual cancer cells and ordinary liver cancer cells is that residual cancer cells experience heat shock. The secretable form of trimeric human tumor necrosis factor-related apoptosis-inducing ligand (stTRAIL) induces apoptosis in a variety of human cancers but not in normal tissues. It has shown potent cancer-selective killing activity and has drawn considerable attention as a possible cancer therapy. In the present work, the therapeutic potential of this stTRAIL-based gene therapy was evaluated in hepatocellular carcinoma subjected to RFA. Rat bone marrow mesenchymal stem cells (BM-MSCs) were isolated and transduced with a lentiviral vector encoding stTRAIL (stTRAIL-MSCs, T-MSCs). Cells treated with heat treatment at 43?°C for 45?min served as simulated residual cancer cells. After treatment with T-MSCs, apoptosis in heat-shock-treated liver cancer cells increased significantly, and caspase-3 was upregulated. When T-MSCs were subcutaneously injected into nude mice, they localized to the tumors and inhibited tumor growth, significantly increasing survival."
According to the news editors, the research concluded: "Collectively, the results of the present study indicate that BM-MSC can provide a steady source of stTRAIL and may be suitable for use in the prevention of the recurrence of hepatocellular carcinoma after RFA with secretable trimeric TRAIL."
For more information on this research see: TRAIL-secreting mesenchymal stem cells promote apoptosis in heat-shock-treated liver cancer cells and inhibit tumor growth in nude mice. Gene Therapy, 2014;21(3):317-27. (Nature Publishing Group - www.nature.com/; Gene Therapy - www.nature.com/gt/)
The news editors report that additional information may be obtained by contacting Q. Deng, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China. Additional authors for this research include Z. Zhang, X. Feng, T. Li, N. Liu, J. Lai, L. Shuai, Q. Xiong, C. Fu, H. Zou, Y. Wang, X. Li, K. Ma and P. Bie (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Oncology, Chongqing, Apoptosis, Therapeutics, Bioengineering, Stem Cell Research, Cancer Gene Therapy, People's Republic of China.
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