News Column

Investigators at Chinese University of Hong Kong Target Nanoparticles

June 3, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Nanoparticles have been presented. According to news reporting from Hong Kong, People's Republic of China, by NewsRx journalists, research stated, "The development of multivalent protein ligands for nanoparticles lags behind that of multidentate polymers and small-molecule ligands largely because of a lack of thorough understanding of the interaction between nanoparticles and multimeric proteins. Guided by protein crystal structures, we have harnessed recombinant technology to develop a collection of mCherry fused multimeric proteins with different spatial distributions of the quantum dot (QD)-binding sequence, hexahistidine tag (histag)."

The news correspondents obtained a quote from the research from the Chinese University of Hong Kong, "All of the proteins can behave as ligands to assemble with ZnS-CdSe QDs through metal-affinity-driven self-assembly. We have observed that protein shape and geometry greatly affect the stoichiometry and stability of their assemblies with QDs. We also demonstrate a peptide-induced structural transition of a nanobelt protein that preorganizes the QD-binding sites and effects a more efficient assembly with QDs. This work reports the first multifaceted investigation on how multivalent proteins, in particular, dimers, tetramers, and linear multidentate proteins, assemble with QDs."

According to the news reporters, the research concluded: "It also manifests our capability of harnessing structural and conformational information about proteins to design multivalent protein ligands for QD surface functionalization."

For more information on this research see: Assembly of multivalent protein ligands and quantum dots: a multifaceted investigation. Langmuir, 2014;30(8):2161-9. (American Chemical Society -; Langmuir -

Our news journalists report that additional information may be obtained by contacting J. Wang, Dept. of Chemistry, The Chinese University of Hong Kong , Shatin, Hong Kong SAR, People's Republic of China. Additional authors for this research include Y. Nie, Y. Lu, J. Liu, J. Wang, A. Fu, T. Liu and J. Xia (see also Nanoparticles).

Keywords for this news article include: Asia, Peptides, Proteins, Hong Kong, Amino Acids, Quantum Dots, Nanotechnology, Quantum Physics, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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