News Column

Investigators at Central University Discuss Findings in Clinical Chemistry

June 3, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Clinical Chemistry have been published. According to news reporting from Oviedo, Spain, by NewsRx journalists, research stated, "The accurate determination of creatinine in serum is essential for the diagnosis and treatment of kidney diseases. The determination of serum creatinine in clinical laboratories is routinely carried out by the Jaffe method or by enzymatic methods that may suffer from interferences."

The news correspondents obtained a quote from the research from Central University, "So, the development of reliable, fast and interference-free routine methods for complex serum samples is required. A fast method using isotope dilution mass spectrometry (IDMS) and gas chromatography mass spectrometry (GC-MS) was developed using minimally C-13 labeled creatinine analogs, multiple linear regression and rapid derivatization of creatinine with acetylacetone in 2 min by using focused microwave technology."

According to the news reporters, the research concluded: "The proposed method was validated with the analyses of two Certified Reference Materials (ERM-DA252a and ERM-DA253a) and compared with the Jaffe and enzymatic methods when analyzing real serum samples containing variable levels of bilirubin The proposed method is capable of providing accurate serum creatinine concentrations in less than 45 min from sample arrival to full data treatment and can be an alternative routine procedure for creatinine determinations in complex serum samples."

For more information on this research see: Development of an isotope dilution GC-MS procedure for the routine determination of creatinine in complex serum samples. Clinica Chimica Acta, 2014;431():96-102. Clinica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Clinica Chimica Acta - www.elsevier.com/wps/product/cws_home/506018)

Our news journalists report that additional information may be obtained by contacting M. Fernandez-Fernandez, Cent Univ Hosp Asturias, Lab Med, Oviedo, Spain. Additional authors for this research include A. Gonzalez-Antuna, P. Rodriguez-Gonzalez, M.E.A. Alvarez, F.V. Alvarez and J.I.G. Alonso (see also Clinical Chemistry).

Keywords for this news article include: Spain, Oviedo, Europe, Clinical Chemistry

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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