News Column

Findings on Neuroinflammation Detailed by Researchers at University of California

June 6, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Neuroinflammation have been published. According to news reporting originating in La Jolla, California, by NewsRx journalists, research stated, "Iron oxide nanoparticles (IONPs) are promising neuroimaging agents and molecular cargo across neurovascular barriers. Development of intrinsically safe IONP chemistries requires a robust in vivo nanoneurotoxicity screening model."

The news reporters obtained a quote from the research from the University of California, "Herein, we engineered four IONPs of different surface and core chemistries: DMSA-Fe2O3, DMSA-Fe3O4, PEG-Fe3O4 and PEG-Au-Fe3O4. Capitalizing on the ability of the peripheral nervous system to recruit potent immune cells from circulation, we characterized a spatiotemporally controlled platform for the study of in vivo nanobiointerfaces with hematogenous immune cells, neuroglial and neurovascular units after intraneural IONP delivery into rat sciatic nerve. SQUID magnetometry and histological iron stain were used for IONP tracking. Among the IONPs, DMSA-Fe2O3 NPs were potent pro-apoptotic agents in nerve, with differential ability to regulate oxidative stress, inflammation and apoptotic signaling in neuroglia, macrophages, lymphocytes and endothelial cells. This platform aims to facilitate the development of predictive paradigms of nanoneurotoxicity based on mechanistic investigation of relevant in vivo bio-nanointerfaces. This team of investigators report the development of a platform that enables screening of iron oxide nanoparticles from the standpoint of their potential neurotoxicity, utilizing rat sciatic nerves."

According to the news reporters, the research concluded: "Such screening tools are clearly needed with the potential advent of iron oxide nanoparticle-based diagnostic and therapeutic approaches."

For more information on this research see: In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms. Nanomedicine, 2013;9(7):1057-66. (Elsevier -; Nanomedicine -

Our news correspondents report that additional information may be obtained by contacting Y. Kim, Dept. of Anesthesiology, University of California, San Diego (UCSD), La Jolla, CA, United States. Additional authors for this research include S.D. Kong, L.H. Chen, T.R. Pisanic, S. Jin and V.I Shubayev (see also Neuroinflammation).

Keywords for this news article include: La Jolla, California, Nanoparticle, United States, Nanotechnology, Neuroinflammation, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Health & Medicine Week

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