News Column

Findings on DNA Research Reported by Investigators at Chang Gung University

June 3, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on DNA Research is now available. According to news reporting out of Taoyuan, Taiwan, by NewsRx editors, research stated, "The magnetic-fluorescent nanoparticles are the integration of fluorophores and magnetic nanopartides (MNP), which are superior to traditional single-modal nanoparticles. Here, we develop magnetic nanoparticles functionalized by acridine orange (ACO) for labeling nucleus and separating DNA."

Our news journalists obtained a quote from the research from Chang Gung University, "The ACO, a cell-permeant nucleic acid binding dye, is conjugated with amine on magnetic nanoparticles by glutaraldehyde-mediated coupling and characterized by TEM and FT-IR. Fluorescence spectroscopy, INCell analyzer, and confocal microscopy analyses confirmed the fluorescent property of ACO modified MNP. Furthermore, the modified magnetic nanoparticles showed strong intracellular fluorescence when incubated with 293T cells for a short period of time. The adsorption capacities measured at various concentrations showed enhanced adsorption capacities for double or single stranded DNA when compared to amine MNP conjugated with glutaraldehyde. The cell viability tests of the composite nanoparticles on 293T cells showed low cytotoxicity indicating the safeness of the nanoparticles."

According to the news editors, the research concluded: "The modified magnetic nanoparticles pave a versatile platform for biological applications such as cell labeling and DNA adsorption."

For more information on this research see: Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption. Colloids and Surfaces B-Biointerfaces, 2014;115():150-156. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also DNA Research).

Our news journalists report that additional information may be obtained by contacting C.H. Liu, Chang Gung University, Grad Inst Biochem & Biomed Engn, Tao Yuan, Taiwan. Additional authors for this research include S.L. Sahoo and M.H. Tsao.

Keywords for this news article include: Asia, Taiwan, Taoyuan, DNA Research, Nanoparticle, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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