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Findings on Cancer Gene Therapy Detailed by Investigators at Affiliated Hospital 1

June 2, 2014



By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting out of Zhejiang, People's Republic of China, by NewsRx editors, research stated, "Pancreatic cancer usually has a poor prognosis, and no gene therapy has yet been developed that is effective to treat it. Since a unique characteristic of bone marrow-derived mesenchymal stem cells (MSCs) is that they migrate to tumor tissues, we wanted to determine whether MSCs could serve as a vehicle of gene therapy for targeting pancreatic cancer."

Our news journalists obtained a quote from the research from Affiliated Hospital 1, "First, we successfully extracted MSCs from SD rats. Next, MSCs were efficiently transduced with NK4, an antagonist of hepatocyte growth factor (HGF) which comprising the N-terminal and the subsequent four kringle domains of HGF, by an adenoviral vector. Then, we confirmed that rat MSCs preferentially migrate to pancreatic cancer cells. Last, MSCs expressing NK4 (NK4-MSCs) strongly inhibited proliferation and migration of the pancreatic cancer cell line SW1990 after co-culture."

According to the news editors, the research concluded: "These results indicate that MSCs can serve as a vehicle of gene therapy for targeting pancreatic cancer."

For more information on this research see: Effect of NK4 Transduction in Bone Marrow-Derived Mesenchymal Stem Cells on Biological Characteristics of Pancreatic Cancer Cells. International Journal of Molecular Sciences, 2014;15(3):3729-3745. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Biotechnology).

Our news journalists report that additional information may be obtained by contacting Y.P. Sun, Wenzhou Med Univ, Affiliated Hosp 1, Dept. of Infect Dis, Wenzhou 325015, Zhejiang, People's Republic of China. Additional authors for this research include B.L. Zhang, J.W. Duan, H.H. Wu, B.Q. Wang, Z.P. Yu, W.J. Yang, Y.F. Shan, M.T. Zhou and Q.Y. Zhang.

Keywords for this news article include: Asia, Biotechnology, Zhejiang, Oncology, Bone Marrow, Bone Research, Immune System, Gastroenterology, Pancreatic Cancer, Stem Cell Research, Cancer Gene Therapy, Pancreatic Neoplasms, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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