News Column

Findings in the Area of Apoptosis Reported from Hadassah-Hebrew University

June 6, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Apoptosis is the subject of a report. According to news reporting from Jerusalem, Israel, by NewsRx journalists, research stated, "The ability to control the movement of nanoparticles remotely and with high precision would have far-reaching implications in many areas of nanotechnology. We have designed a unique dynamic magnetic field (DMF) generator that can induce rotational movements of superparamagnetic iron oxide nanoparticles (SPIONs)."

The news correspondents obtained a quote from the research from Hadassah-Hebrew University, "We examined whether the rotational nanoparticle movement could be used for remote induction of cell death by injuring lysosomal membrane structures. We further hypothesized that the shear forces created by the generation of oscillatory torques (incomplete rotation) of SPIONs bound to lysosomal membranes would cause membrane permeabilization, lead to extravasation of lysosomal contents into the cytoplasm, and induce apoptosis. To this end, we covalently conjugated SPIONs with antibodies targeting the lysosomal protein marker LAMP1 (LAMP1-SPION). Remote activation of slow rotation of LAMP1-SPIONs significantly improved the efficacy of cellular internalization of the nanoparticles. LAMP1-SPIONs then preferentially accumulated along the membrane in lysosomes in both rat insulinoma tumor cells and human pancreatic beta cells due to binding of LAMP1-SPIONs to endogenous LAMP1. Further activation of torques by the LAMP1-SPIONs bound to lysosomes resulted in rapid decrease in size and number of lysosomes, attributable to tearing of the lysosomal membrane by the shear force of the rotationally activated LAMP1-SPIONs. This remote activation resulted in an Increased expression of early and late apoptotic markers and impaired cell growth."

According to the news reporters, the research concluded: "Our findings suggest that DMF treatment of lysosome-targeted nanoparticles offers a noninvasive tool to induce apoptosis remotely and could serve as an important platform technology for a wide range of biomedical applications."

For more information on this research see: Dynamic Magnetic Fields Remote-Control Apoptosis via Nanoparticle Rotation. ACS Nano, 2014;8(4):3192-3201. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)

Our news journalists report that additional information may be obtained by contacting E.M. Zhang, Hadassah Hebrew Univ, Medical Center, Dept. of Radiol, Div Image Guided Therapy & Intervent Oncol, Jerusalem, Israel. Additional authors for this research include M.F. Kircher, M. Koch, L. Eliasson, S.N. Goldberg and E. Renstrom (see also Apoptosis).

Keywords for this news article include: Asia, Israel, Jerusalem, Apoptosis, Lysosomes, Nanoparticle, Nanotechnology, Intracellular Space, Cytoplasmic Vesicles, Emerging Technologies, Cytoplasmic Structures

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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