News Column

Findings from Kaohsiung Medical University in the Area of Magnetic Resonance Reported

June 6, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Magnetic Resonance is now available. According to news reporting originating from Kaohsiung, Taiwan, by NewsRx correspondents, research stated, "A novel dual functional theranosis platform is developed based on manganese magnetism-engineered iron oxide (MnMEIO) and gold nanorods (AuNRs) to combine magnetic resonance (MR) imaging and photothermal therapy in one nanocluster. The platform showed improved T-2-weighted MR imaging and exhibited a near-infrared (NIR) induced temperature elevation due to the unique characteristics of AuNRs@MnMEIOs nanoclusters."

Our news editors obtained a quote from the research from Kaohsiung Medical University, "The obtained dual functional spherical-shaped nanoclusters showed low cytotoxicity, and high cellular uptake efficiency. The AuNRs@MnMEIOs nanoclusters also demonstrated a 1.9 and 2.2 folds r(2) relaxivity value higher than those of monodispersed MnMEIO and Resovist. In addition, in vivo MR imaging study found that the contrast enhancements were -70.4 +/- 4.3% versus 7.5 +/- 3.0% in Her-2/neu overexpression tumors as compared to the control tumors. More importantly, NIR laser irradiation to the tumor site resulted in outstanding photothermal therapeutic efficacy and without damage to the surrounding tissue. In additional, the prepared dual functional AuNRs@MnMEIOs display high stability and furthermore disperse even in the presence of external magnet, showing that AuNRs@MnMEIOs nanoclusters can be manipulated by an external magnetic field."

According to the news editors, the research concluded: "Therefore, such nanoclusters combined MR imaging and photothermal therapeutic functionality can be developed as a promising nanosystem for effective cancer diagnosis and therapy."

For more information on this research see: Dual functional AuNRs@MnMEIOs nanoclusters for magnetic resonance imaging and photothermal therapy. Biomaterials, 2014;35(16):4678-4687. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

The news editors report that additional information may be obtained by contacting Y.C. Chuang, Kaohsiung Medical University, Dept. of Biomed Sci & Environm Biol, Kaohsiung 80708, Taiwan. Additional authors for this research include C.J. Lin, S.F. Lo, J.L. Wang, S.C. Tzou, S.S. Yuan and Y.M. Wang (see also Magnetic Resonance).

Keywords for this news article include: Asia, Taiwan, Therapy, Kaohsiung, Magnetic Resonance

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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