News Column

Findings from First Affiliated Hospital Provides New Data on Taxoids

June 3, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Taxoids. According to news originating from Zhengzhou, People's Republic of China, by NewsRx correspondents, research stated, "Single-walled carbon nanotubes (SWCNTs) have unique transmembrane abilities. The huge superficial area and abundance of ? electrons confer SWCNTs perfect absorptive capability toward proteins, nucleates, and many drugs."

Our news journalists obtained a quote from the research from First Affiliated Hospital, "These characteristics make SWCNTs a new and efficient drug carrier. The purpose of this study was to disperse SWCNTs in water and have paclitaxel absorbed onto them in order to construct an asparagine-glycine-arginine (NGR)-SWCNT-Paclitaxel complex as a targeting nanoparticle system. The NGR-SWCNT-Paclitaxel complex was systematically studied, and analytical methods, including spectrophotometry for SWCNTs and high-performance liquid chromatography for paclitaxel, were employed. The preparation and the prescription of the NGR-SWCNT-Paclitaxel complex lyophilized powder were investigated. MCF-7 cancer cells, Sprague-Dawley rats, and S180 tumor-bearing mice were used as experimental subjects to evaluate the in vitro and in vivo activity of NGR-SWCNT-Paclitaxel complex dispersion. The complex dispersion showed obvious inhibition activity against MCF-7 cancer cells. Within 1 h, the NGR-SWCNT-Paclitaxel complex could be transferred to cells, and sustained the release of drugs."

According to the news editors, the research concluded: "In addition, the tumor and liver targeting and improved therapeutic effects of the NGR-SWCNT-Paclitaxel complex were confirmed."

For more information on this research see: Preparation and biological activity of a paclitaxel-single-walled carbon nanotube complex. Genetics and Molecular Research [electronic Resource], 2014;13(1):1589-603 (see also Taxoids).

The news correspondents report that additional information may be obtained from X.D. Fu, Dept. of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China. Additional authors for this research include Y.Y. Zhang, X.J. Wang, J.X. Shou, Z.Z. Zhang and L.J Song.

Keywords for this news article include: Asia, Taxoids, Terpenes, Zhengzhou, Fullerenes, Paclitaxel, Hydrocarbons, Cycloparaffins, Nanotechnology, Organic Chemicals, Emerging Technologies, People's Republic of China, Single Walled Carbon Nanotubes.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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