By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanoparticles is the subject of a report. According to news reporting out of Gyeongbuk, South Korea, by NewsRx editors, research stated, "Malaria, a major burden of disease caused by parasites of the genus Plasmodium, is widely spread in tropical and subtropical regions. Here, we have successfully developed a diagnostic technique for malaria."
Our news journalists obtained a quote from the research from the Pohang University of Science and Technology (POSTECH), "The proposed method is based on the interaction among the Plasmodium lactate dehydrogenase (pLDH), which is a biomarker for malaria, and pL1 aptamer against Plasmodium vivax lactate dehydrogenase (PvLDH) and Plasmodium falciparum lactate dehydrogenase (PfLDH). In addition, the cationic polymers, poly(diallyldimethylammonium chloride) (PDDA) and poly(allylamine hydrochloride) (PAH), aggregate gold nanoparticles (AuNPs) that should be possible to observe the change in color from red to blue, which depends on the concentration of pLDH. Using this aptasensor, pLDH proteins were successfully detected with low detection limits. Moreover, the specificity test proved that the aptasenor is very specific in targeting proteins over other interfering proteins. In addition, the pLDH from infected blood samples of the two main species of malaria were also detected. The limits of detection for P. vivax were determined as 80 parasites/?l for PDDA and 74 parasites/?l for PAH. The aptasenor has great advantages that can simply and rapidly diagnose malaria."
According to the news editors, the research concluded: "Thus, the developed aptasensor for detection of pLDH can offer an effective and sensitive diagnosis of malaria."
For more information on this research see: A colorimetric aptasensor for the diagnosis of malaria based on cationic polymers and gold nanoparticles. Analytical Biochemistry, 2013;439(1):11-6. (Elsevier - www.elsevier.com; Analytical Biochemistry - www.elsevier.com/wps/product/cws_home/622781)
Our news journalists report that additional information may be obtained by contacting W. Jeon, Dept. of Chemistry, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, South Korea. Additional authors for this research include S. Lee, D.H. Manjunatha and C. Ban (see also Nanoparticles).
Keywords for this news article include: Asia, Peptides, Proteins, Gyeongbuk, South Korea, Amino Acids, Dehydrogenase, Nanotechnology, Emerging Technologies, Enzymes and Coenzymes.
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