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Study Findings from Emory University Provide New Insights into Molecular Recognition

May 30, 2014



By a News Reporter-Staff News Editor at Science Letter -- New research on Molecular Recognition is the subject of a report. According to news originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated aminoglycoside-resistance rRNA methyltransferase A (NpmA)."

Our news journalists obtained a quote from the research from Emory University, "These studies are supported by biochemical and functional assays that define the molecular features necessary for NpmA to catalyze m(1)A1408 modification and confer resistance. The requirement for the mature 30S as a substrate for NpmA is clearly explained by its recognition of four disparate 16S rRNA helices brought into proximity by 30S assembly. Our structure captures a 'precatalytic state' in which multiple structural reorganizations orient functionally critical residues to flip A1408 from helix 44 and position it precisely in a remodeled active site for methylation."

According to the news editors, the research concluded: "Our findings provide a new molecular framework for the activity of aminoglycoside-resistance rRNA methyltransferases that may serve as a functional paradigm for other modification enzymes acting late in 30S biogenesis."

For more information on this research see: Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(17):6275-6280. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)

The news correspondents report that additional information may be obtained from J.A. Dunkle, Emory University, Sch Med, Dept. of Biochem, Atlanta, GA 30322, United States. Additional authors for this research include K. Vinal, P.M. Desai, N. Zelinskaya, M. Savic, D.M. West, G.L. Conn and C.M. Dunham (see also Molecular Recognition).

Keywords for this news article include: Atlanta, Georgia, United States, Nanotechnology, Emerging Technologies, Molecular Recognition, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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