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New Supramolecular Research Study Findings Have Been Reported by Researchers at Wuhan University

May 30, 2014

By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Supramolecular Research. According to news originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "Spontaneous formation of supramolecular vesicles which are triggered by the formation of [4]pseudorotaxane B was demonstrated, whereas both Guest and [2]pseudorotaxane A, the precursors of [4]pseudorotaxane B, only assemble into micelles in DMF/water solution. The remarkable transformation of Guest from micelles to supramolecular vesicles was confirmed through DLS, TEM, and Cryo-TEM experiments."

Our news journalists obtained a quote from the research from Wuhan University, "The cumulative release of a model drug, 5-carboxyfluorescein (CF), was used to determine the permeability of the supramolecular vesicles. No leakage of entrapped CF was observed within 48 h by fluorescence measurement, indicating the high stability of supramolecular vesicles. The formation mechanism of supramolecular vesicles self-assembled by [4]pseudorotaxane B was also discussed. In [4]pseudorotaxane B, CB[6] is used to increase the hydrophobic property of site ?, which acts as hydrophobic 'tail.' Meanwhile, CB[7] plays the role of increasing 'head area' of site ?, which acts as hydrophilic 'head.' The synergistic effect of CB[6] and CB[7] induces the formation of supramolecular vesicles. Moreover, the effect of DMF content was investigated by TEM observations."

According to the news editors, the research concluded: "It was found that the [4]pseudorotaxane B can self-assemble into regular supramolecular vesicles when the DMF content is in the range of 50-70%."

For more information on this research see: Transformation of micelles into supramolecular vesicles triggered by the formation of [4]pseudorotaxanes. Journal of Colloid and Interface Science, 2013;410():131-9. (Elsevier -; Journal of Colloid and Interface Science -

The news correspondents report that additional information may be obtained from Q. Zhou, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China. Additional authors for this research include D. Gao, J. Liu, X. Sun, L. Zhang, B. Qi, H. Zhang, C. Xia and X. Zhou (see also Supramolecular Research).

Keywords for this news article include: Asia, Wuhan, Nanotechnology, Emerging Technologies, Supramolecular Research, People's Republic of China.

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Source: Science Letter

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