News Column

Investigators at University College Cork Report New Data on Proteomics

May 30, 2014



By a News Reporter-Staff News Editor at Science Letter -- Data detailed on Proteomics have been presented. According to news reporting originating in Cork, Ireland, by NewsRx journalists, research stated, "Recent decades have seen a strong increase in the promise and uses of nanotechnology. This is correlated with their growing release in the environment and there is concern that nanomaterials may endanger ecosystems."

The news reporters obtained a quote from the research from University College Cork, "Silver nanoparticles (AgNPs) have some of the most varied applications, making their release into the environment unavoidable. In order to assess their potential toxicity in aquatic environments, the acute toxicity of citrate-coated AgNPs to Daphnia magna was measured and compared to that of AgNO3. AgNPs were found to be ten times less toxic by mass than silver ions, and most of this toxicity was removed by ultracentrifuging. At the protein level, the two forms of silver had different impacts. Both increased protein thiol content, while only AgNP increased carbonyl levels. In 2DE of samples labelled for carbonyls, no feature was significantly affected by both compounds, indicating different modes of toxicity. Identified proteins showed functional overlap between the two compounds: vitellogenins (vtg) were present in most features identified, indicating their role as a general stress sensor. In addition to vtg, hemoglobin levels were increased by the AgNP exposure while 14-3-3 protein (a regulatory protein) carbonylation levels were reduced by AgNO3."

According to the news reporters, the research concluded: "Overall, this study confirms the previously observed lower acute toxicity of AgNPs, while demonstrating that the toxicity of both forms of silver follow somewhat different biologic pathways, potentially leading to different interactions with natural compounds or pollutants in the aquatic environment."

For more information on this research see: Proteomic evaluation of citrate-coated silver nanoparticles toxicity in Daphnia magna. Analyst, 2014;139(7):1678-86. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)

Our news correspondents report that additional information may be obtained by contacting L.C. Rainville, Proteomics Research Group, School of Biochemistry and Cell Biology, University College Cork, Western Gateway Building 399, Western Road, Cork, Ireland. Additional authors for this research include D. Carolan, A.C. Varela, H. Doyle and D. Sheehan (see also Proteomics).

Keywords for this news article include: Cork, Europe, Ireland, Proteomics, Nanoparticle, Nanotechnology, Emerging Technologies.

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Source: Science Letter