News Column

Findings from Technical University Broaden Understanding of DNA Research

May 30, 2014

By a News Reporter-Staff News Editor at Science Letter -- Data detailed on DNA Research have been presented. According to news originating from Garching, Germany, by NewsRx correspondents, research stated, "Molecular self-assembly with DNA is an attractive route for building nanoscale devices. The development of sophisticated and precise objects with this technique requires detailed experimental feedback on the structure and composition of assembled objects."

Our news journalists obtained a quote from the research from Technical University, "Here we report a sensitive assay for the quality of assembly. The method relies on measuring the content of unpaired DNA bases in self-assembled DNA objects using a fluorescent de-Bruijn probe for three-base 'codons', which enables a comparison with the designed content of unpaired DNA. We use the assay to measure the quality of assembly of several multilayer DNA origami objects and illustrate the use of the assay for the rational refinement of assembly protocols. Our data suggests that large and complex objects like multilayer DNA origami can be made with high strand integration quality up to 99%."

According to the news editors, the research concluded: "Beyond DNA nanotechnology, we speculate that the ability to discriminate unpaired from paired nucleic acids in the same macromolecule may also be useful for analysing cellular nucleic acids."

For more information on this research see: Quantifying quality in DNA self-assembly. Nature Communications, 2014;5():60-66. Nature Communications can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Communications -

The news correspondents report that additional information may be obtained from K.F. Wagenbauer, Technical University of Munich, Walter Schottky Inst, Physik Department, D-85748 Garching, Germany. Additional authors for this research include C.H. Wachauf and H. Dietz (see also DNA Research).

Keywords for this news article include: Europe, Germany, Garching, DNA Research

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Source: Science Letter

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