News Column

Yonsei University Reports Findings in Stem Cells

May 28, 2014

By a News Reporter-Staff News Editor at Biotech Week -- New research on Stem Cell Research is the subject of a report. According to news reporting originating from Wonju, South Korea, by NewsRx correspondents, research stated, "Mesenchymal stem cells (MSCs) are an active topic of research in regenerative medicine due to their ability to secrete a variety of growth factors and cytokines that promote healing of damaged tissues and organs. In addition, these secreted growth factors and cytokines have been shown to exert an autocrine effect by regulating MSC proliferation and differentiation."

Our news editors obtained a quote from the research from Yonsei University, "We found that expression of EGF, FGF-4 and HGF were down-regulated during serial passage of bone marrow-derived mesenchymal stem cells (BMSCs). Proliferation and differentiation potentials of BMSCs treated with these growth factors for 2 months were evaluated and compared to BMSCs treated with FGF-2, which increased proliferation of BMSCs. FGF-2 and -4 increased proliferation potentials at high levels, about 76-and 26-fold, respectively, for 2 months, while EGF and HGF increased proliferation of BMSCs by less than 2.8-fold. Interestingly, differentiation potential, especially adipogenesis, was maintained only by HGF treatment. Treatment with FGF-2 rapidly induced activation of AKT and later induced ERK activation. The basal level of phosphorylated ERK increased during serial passage of BMSCs treated with FGF-2. The expression of LC3-II, an autophagy marker, was gradually increased and the population of senescent cells was increased dramatically at passage 7 in non-treated controls. But FGF-2 and FGF-4 suppressed LC3-II expression and down-regulated senescent cells during long-term (i.e. 2month) cultures."

According to the news editors, the research concluded: "Taken together, depletion of growth factors during serial passage could induce autophagy, senescence and down-regulation of stemness (proliferation via FGF-2/-4 and differentiation via HGF) through suppression of AKT and ERK signaling."

For more information on this research see: The role of growth factors in maintenance of stemness in bone marrow-derived mesenchymal stem cells. Biochemical and Biophysical Research Communications, 2014;445(1):16-22. (Elsevier -; Biochemical and Biophysical Research Communications -

The news editors report that additional information may be obtained by contacting Y.W. Eom, Cell Therapy and Tissue Engineering Center, Wonju College of Medicine, Yonsei Univ, Wonju, South Korea. Additional authors for this research include J.E. Oh, J.I. Lee, S.K. Baik, K.J. Rhee, H.C. Shin, Y.M. Kim, C.M. Ahn, J.H. Kong, H.S. Kim and K.Y Shim (see also Stem Cell Research).

Keywords for this news article include: Asia, Biomedical Engineering, Biomedicine, Wonju, South Korea, Bone Marrow, Bone Research, Immune System, Bioengineering, Stem Cell Research, Regenerative Medicine, Mesenchymal Stem Cells.

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Source: Biotech Week