News Column

Study Results from Sun Yat-Sen University in the Area of Fetal Proteins Reported

May 27, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Proteins. According to news reporting originating in Guangdong, People's Republic of China, by NewsRx journalists, research stated, "Surface-enhanced Raman scattering (SERS) signals strongly rely on the interactions and distance between analyte molecules and metallic nanostructures. In this work, the use of a gold nanoparticle (AuNP)-embedded metal-organic framework was introduced for the highly sensitive SERS detection."

The news reporters obtained a quote from the research from Sun Yat-Sen University, "The AuNPs were in situ grown and encapsulated within the host matrix of MIL-101 by a solution impregnation strategy. The as-synthesized AuNPs/MIL-101 nanocomposites combined the localized surface plasmon resonance properties of the gold nanoparticles and the high adsorption capability of metal organic framework, making them highly sensitive SERS substrates by effectively preconcentrating analytes in close proximity to the electromagnetic fields at the SERS-active metal surface. We discussed the fabrication, physical characterization, and SERS activity of our novel substrates by measuring the Raman signals of a variety of model analytes. The SERS substrate was found to be highly sensitive, robust, and amiable to several different target analytes. A SERS detection limit of 41.75 and 0.54 fmol for Rhodamine 6G and benzadine, respectively, was demonstrated. The substrate also showed high stability and reproducibility, as well as molecular sieving effect thanks to the protective shell of the metal organic framework. Subsequently, the potential practical application of the novel SERS substrate was evaluated by quantitative analysis of organic pollutant p-phenylenediamine in environmental water and tumor marker alpha-fetoprotein in human serum. The method showed good linearity between 1.0 and 100.0 ng/mL for p-phenylenediamine and 1.0-130.0 ng/mL for alpha-fetoprotein with the correlation coefficients of 0.9950 and -0.9938, respectively. The recoveries ranged from 80.5% to 114.7% for p-phenylenediamine in environmental water and 79.3% to 107.3% for alpha-fetoprotein in human serum."

According to the news reporters, the research concluded: "These results foresee promising application of the novel metal-organic framework based composites as sensitive SERS-active substrates in both environmental and clinical samples."

For more information on this research see: Fabrication of Gold Nanoparticle-Embedded Metal-Organic Framework for Highly Sensitive Surface-Enhanced Raman Scattering Detection. Analytical Chemistry, 2014;86(8):3955-3963. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Analytical Chemistry -

Our news correspondents report that additional information may be obtained by contacting Y.L. Hu, Sun Yat Sen UniversitySch Chem & Chem Engn, Guangzhou 510275, Guangdong, People's Republic of China. Additional authors for this research include J. Liao, D.M. Wang and G.K. Li (see also Proteins).

Keywords for this news article include: Asia, Guangdong, Fetal Proteins, Nanotechnology, Aniline Compounds, Phenylenediamines, Gold Nanoparticles, alpha-Fetoproteins, Emerging Technologies, Biological Tumor Markers, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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