News Column

Study Results from Kyoto University Provide New Insights into DNA Research

May 27, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on DNA Research are presented in a new report. According to news reporting originating in Kyoto, Japan, by NewsRx journalists, research stated, "The present theoretical investigation aims at understanding the origin of enantioselectivity of intramolecular Friedel-Crafts reaction, catalyzed by supramolecular Cu/DNA catalyst. 28 Conformations of the supramolecular L-Cu(II)-R/d(CAAAAATTTTTG)(2) complex were thoroughly modeled to estimate their stability and structural features depending on the metal complex conformation and its intercalation position."

The news reporters obtained a quote from the research from Kyoto University, "The preferred formation of S-product can be rationalized by the higher binding energy of pro-S conformations to DNA."

According to the news reporters, the research concluded: "Pro-S conformations are structurally closer to the expected C3-C2' bond formation TS and usually not deeply buried into DNA, which would facilitate TS formation by decreasing the energy for conformational changes."

For more information on this research see: The origin of enantioselectivity for intramolecular Friedel-Crafts reaction catalyzed by supramolecular Cu/DNA catalyst complex. Chemical Physics Letters, 2014;600():87-95. Chemical Physics Letters can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Chemical Physics Letters -

Our news correspondents report that additional information may be obtained by contacting G.P. Petrova, Kyoto University, Grad Sch Sci, Dept. of Chem, Kyoto 6068502, Japan. Additional authors for this research include Z.F. Ke, S. Park, H. Sugiyama and K. Morokuma (see also DNA Research).

Keywords for this news article include: Asia, Kyoto, Japan, DNA Research, Nanotechnology, Supramolecular, Emerging Technologies

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Source: Life Science Weekly

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