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Study Results from Guangxi University Provide New Insights into Mutagenesis

May 30, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Mutagenesis is now available. According to news reporting originating in Guangxi, People's Republic of China, by NewsRx journalists, research stated, "Gluconobacter oxydans, belonging to acetic acid bacteria, is widely used in industrial biotechnology. In our previous study, one of the main glucose metabolic pathways in G. oxydans 621H was blocked by the disruption of the mgdh gene, which is responsible for glucose oxidation to gluconate on cell membrane."

The news reporters obtained a quote from the research from Guangxi University, "The resulting 621H Delta mgdh mutant strain showed an enhanced growth and biomass yield on glucose. In order to further understand the intracellular utilization of glucose by 621H Delta mgdh, the functions of four fundamental genes, namely glucokinase-encoding glk1 gene, soluble glucose dehydrogenase-encoding sgdh gene, galactose-proton symporter-encoding galp1 and galp2 genes, were investigated. The obtained metabolic characteristics of 621H Delta mgdh Delta glk1 and 621H Delta mgdh Delta sgdh double-gene knockout mutants showed that, in vivo, glucose is preferentially phosphorylated to glucose-6-phosphate by glucokinase rather than being oxidized to gluconate by soluble glucose dehydrogenase."

According to the news reporters, the research concluded: "In addition, although the galactose-proton symporter-encoding genes were proved to be glucose transporter genes in other organisms, both galp genes (galp 1 and galp2) in G. oxydans were not found to be involved in glucose uptake system, implying that other unknown transporters might be responsible for transporting glucose into the cells."

For more information on this research see: Revealing in vivo glucose utilization of Gluconobacter oxydans 621H Delta mgdh strain by mutagenesis. Microbiological Research, 2014;169(5-6):469-475. Microbiological Research can be contacted at: Elsevier Gmbh, Urban & Fischer Verlag, Office Jena, P O Box 100537, 07705 Jena, Germany. (Elsevier - www.elsevier.com; Microbiological Research - www.elsevier.com/wps/product/cws_home/701785)

Our news correspondents report that additional information may be obtained by contacting L.J. Wei, Guangxi Univ, Coll Life Sci & Technol, Nanning 530005, Guangxi, People's Republic of China. Additional authors for this research include D.N. Zhu, J.L. Zhou, J.J. Zhang, K. Zhu, L.Q. Du and Q. Hua (see also Mutagenesis).

Keywords for this news article include: Asia, Guangxi, Mutagenesis, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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