News Column

Study Results from Chang Gung Memorial Hospital in the Area of Angiology Reported

May 30, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Angiology have been presented. According to news reporting originating from Taoyuan, Taiwan, by NewsRx correspondents, research stated, "Incomplete endothelialization and neointimal hyperplasia of injured arteries can cause acute and late stent thromboses. This work develops hybrid stent/biodegradable nanofibers for the local and sustained delivery of rosuvastatin to denuded artery walls."

Our news editors obtained a quote from the research from Chang Gung Memorial Hospital, "Biodegradable nanofibers were firstly prepared by dissolving poly(D,L)-lactide-co-glycolide and rosuvastatin in 1,1,1,3,3,3-hexafluoro-2-propanol. The solution was then electrospun into nanofibrous tubes, which were mounted onto commercially available bare-metal stents. The in vitro release rates of the pharmaceuticals from the nanofibers were determined using an elution method and a high-performance liquid chromatography assay. The experimental results thus obtained suggest that the biodegradable nanofibers released high concentrations of rosuvastatin for four weeks. The effectiveness of the local delivery of rosuvastatin in reducing platelets was studied. The tissue inflammatory reaction caused by the hybrid stents that were used to treat diseased arteries was also documented. The proposed hybrid stent/biodegradable rosuvastatin-loaded nanofibers contributed substantially to the local and sustainable delivery of a high concentration of drugs to promote re-endothelialization, improve endothelial function, reduce inflammatory reaction, and inhibit neointimal formation of the injured artery."

According to the news editors, the research concluded: "The results of this work provide insight into how patients with a high risk of stent restenosis should be treated for accelerating re-endothelialization and inhibiting neointimal hyperplasia."

For more information on this research see: Acceleration of re-endothelialization and inhibition of neointimal formation using hybrid biodegradable nanofibrous rosuvastatin-loaded stents. Biomaterials, 2014;35(15):4417-4427. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

The news editors report that additional information may be obtained by contacting C.H. Lee, Chang Gung Memorial Hospital, Dept. of Med Imaging & Intervent, Tao Yuan, Taiwan. Additional authors for this research include S.H. Chang, Y.H. Lin, S.J. Liu, C.J. Wang, M.Y. Hsu, K.C. Hung, Y.H. Yeh, W.J. Chen, I.C. Hsieh and M.S. Wen (see also Angiology).

Keywords for this news article include: Asia, Taiwan, Taoyuan, Angiology, Nanofiber, Nanotechnology, Emerging Technologies

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Source: Health & Medicine Week

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