Our news journalists obtained a quote from the research, "Preexisting humoral and cellular immunity against common HAdV serotypes limits the efficacy of gene transfer and duration of transgene expression. As an alternative, nonhuman AdV (NHAdV) vectors can circumvent neutralizing antibodies against HAdVs in immunized mice and monkeys and in human sera, suggesting that NHAdV vectors could circumvent preexisting humoral immunity against HAdVs in a clinical setting. Consequently, there has been an increased interest in developing NHAdV vectors for gene delivery in humans."
According to the news editors, the research concluded: "In this review, we outline the recent advances and limitations of HAdV vectors for gene therapy and describe examples of NHAdV vectors focusing on their immunogenicity, tropism, and potential as effective gene therapy vehicles."
For more information on this research see: Circumventing Antivector Immunity: Potential Use of Nonhuman Adenoviral Vectors. Human Gene Therapy, 2014;25(4):285-300. Human Gene Therapy can be contacted at:
The news correspondents report that additional information may be obtained from
Keywords for this news article include: Biotechnology, Spain,
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