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Study Data from Research Institute Provide New Insights into Stem Cells

May 28, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting out of Columbus, Ohio, by NewsRx editors, research stated, "Bone morphogenetic proteins (BMPs) initiate, promote, and maintain odontogenesis and osteogenesis. In this study, we studied the effect of bone morphogenic protein 2 (BMP 2) and bone morphogenic protein 7 (BMP 7) as differentiation inducers in tooth and bone regeneration."

Our news journalists obtained a quote from the research from Research Institute, "We compared the effect of BMP 2 and BMP 7 on odontogenic and osteogenic differentiation of human tooth germ stem cells (hTGSCs). Third molar-derived hTGSCs were characterized with mesenchymal stem cell surface markers by flow cytometry. BMP 2 and BMP 7 were transfected into hTGSCs and the cells were seeded onto six-well plates. One day after the transfection, hTGSCs were treated with odontogenic and osteogenic mediums for 14 days. For confirmation of odontogenic and osteogenic differentiation, mRNA levels of BMP2, BMP 7, collagen type 1 (COL1A), osteocalsin (OCN), and dentin sialophosphoprotein (DSPP) genes were measured by quantitative real-time PCR. In addition to this, immunocytochemistry was performed by odontogenic and osteogenic antibodies and mineralization obtained by von Kossa staining. Our results showed that the BMP 2 and BMP 7 both promoted odontogenic and osteogenic differentiation of hTGSCs. Data indicated that BMP 2 treatment and BMP 7 treatment induce odontogenic differentiation without affecting each other, whereas they induce osteogenic differentiation by triggering expression of each other."

According to the news editors, the research concluded: "These findings provide a feasible tool for tooth and bone tissue engineering."

For more information on this research see: Bmp 2 and Bmp 7 Induce Odonto- And Osteogenesis of Human Tooth Germ Stem Cells. Applied Biochemistry and Biotechnology, 2014;172(6):3016-3025. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)

Our news journalists report that additional information may be obtained by contacting P.N. Tasli, Nationwide Childrens Hosp, Res Inst, Center Gene Therapy, Columbus, OH 43205, United States. Additional authors for this research include S. Aydin, M.E. Yalvac and F. Sahin (see also Stem Cell Research).

Keywords for this news article include: Ohio, Tissue Engineering, Biomedical Engineering, Biomedicine, Columbus, United States, Bone Research, Bioengineering, Bone Regeneration, Stem Cell Research, Regeneration Medicine, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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