News Column

Studies from Nanjing University Describe New Findings in Nanoparticles

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting originating in Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Based on the fact that the transcription of STAT-1 plus its Serine 727 and Tyrosine 701 phosphorylation is not the pre-requisite for the cell death signal transduction in the IFN-gamma signaling pathway induced by co-immobilized IFN-gamma/TNF-alpha, we investigate both in vitro and in vivo the key transcription regulators to promote the signal transduction of HeLa cells. It is found that IFN-gamma R2 is the important death signal receptor in the HeLa cell death by RNA interference."

The news reporters obtained a quote from the research from Nanjing University, "Checking the expression of the whole transcription (STAT) protein family reveals that STAT-6 is highly expressed in comparison with the other STAT proteins. The gene silence of IFN-gamma R2 leads to the down-regulation of STAT-6 and phosphorylation-STAT-6 (p-STAT-6) expressions. The successful gene silence of STAT-6 results in the reduction of HeLa cell programmed death and the expression of several important key factors related to programmed cell death (p53, Bc1-2, and Bax). More importantly, our in vivo experiments by injecting nanoparticle drug carriers with the co-immobilized IFN-gamma/TNF-alpha into nude mice model confirm the high expression of STAT-6 and p-STAT-6. It is thus concluded that, in response to IFN-gamma, the co-immobilized IFN-gamma/TNF-alpha unusually promotes the activation of STAT-6 rather than STAT-1, resulting in the enhanced cell programmed death in HeLa."

According to the news reporters, the research concluded: "The present work reveals the gene-level molecular mechanism of IFN-gamma/TNF-alpha co-immobilized on biomaterials as a potentially effective therapy against cancer cells."

For more information on this research see: The role of STAT-6 as a key transcription regulator in He La cell death induced by IFN-gamma/TNF-alpha co-immobilized on nanoparticles. Biomaterials, 2014;35(18):5016-5027. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)

Our news correspondents report that additional information may be obtained by contacting Z.B. Li, Nanjing University, Solid State Microstruct Lab, Nanjing 210093, Jiangsu, People's Republic of China. Additional authors for this research include Y.Q. Guan and J.M. Liu (see also Nanoparticles).

Keywords for this news article include: Asia, Jiangsu, Nanotechnology, Emerging Technologies, People's Republic of China

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Source: Life Science Weekly