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Studies from Moscow State University Further Understanding of Applied Microbiology and Biotechnology

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in Moscow, Russia, by NewsRx journalists, research stated, "Decontamination of soils with complex pollution using natural strains of microorganisms is a matter of great importance. Here we report that oil-oxidizing bacteria Rhodococcus erythropolis AC-1514D and Rhodococcus ruber AC-1513D can degrade various organophosphorous pesticides (OP)."

The news reporters obtained a quote from the research from Moscow State University, "Cell-mediated degradation of five different OP is apparently associated with the presence of N-acylhomoserine lactonase, which is pronouncedly similar (46-50 %) to the well-known enzyme organophosphate hydrolase (OPH), a hydrolysis catalyst for a wide variety of organophosphorous compounds. Additionally, we demonstrated the high lactonase activity of hexahistidine-tagged organophosphate hydrolase (His6-OPH) with respect to various N-acylhomoserine lactones, and we determined the catalytic constants of His6-OPH towards these compounds. These experimental data and theoretical analysis confirmed the hypothesis about the evolutionary proximity of OPH and lactonases. Using Rhodococcus cells, we carried out effective simultaneous biodegradation of pesticide paraoxon (88 mg/kg) and oil hydrocarbon hexadecane (6.3 g/kg) in the soil."

According to the news reporters, the research concluded: "Furthermore, the discovered high lactonase activity of His6-OPH offers new possibilities for developing an efficient strategy of combating resistant populations of Gram-negative bacterial cells."

For more information on this research see: Rhodococcus lactonase with organophosphate hydrolase (OPH) activity and His?-tagged OPH with lactonase activity: evolutionary proximity of the enzymes and new possibilities in their application. Applied Microbiology and Biotechnology, 2014;98(6):2647-56. (Springer - www.springer.com; Applied Microbiology and Biotechnology - www.springerlink.com/content/0175-7598/)

Our news correspondents report that additional information may be obtained by contacting M. Sirotkina, Moscow State University, Lenin's Hills 1, 11, 119991, Moscow, Russia (see also Life Science Research).

Keywords for this news article include: Moscow, Russia, Eurasia, Enzymes and Coenzymes, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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