News Column

Studies Conducted at Jilin University on Chromosome Structures Recently Reported

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Chromosome Structures is the subject of a report. According to news reporting out of Changchun, People's Republic of China, by NewsRx editors, research stated, "Chiral recognition of DNA molecules is important because DNA chiral transition and its different conformations are involved in a series of important life events. Among them, polymorphic human telomere DNA has attracted great interests in recent years because of its important roles in chromosome structural integrity."

Our news journalists obtained a quote from the research from Jilin University, "In this report, we examine the short-term effect of chiral metallo-supramolecular complex enantiomers treatment on tumor cells, and find that a zinc-finger-like alpha helical chiral metallo-supramolecular complex, [Ni2L3](4+)-P enantiomer (NiP), can selectively provoke the rapid telomere uncapping, trigger DNA damage responses at telomere and degradation of G-overhang and the delocalization of telomeric protein from telomeres. Further studies indicate that NiP can induce an acute cellular apoptosis and senescence in cancer cells rather than normal cells. These results are further evidenced by the upregulation of p21 and p16 proteins. Moreover, NiP can cause translocation of hTERT from nuclear to cytoplasm through Tyr 707 phosphorylation. While its enantiomer, [Ni2L3](4+)-M (NiM), has no such mentioned effects, these results clearly demonstrate the compound's chiral selectivity in cancer cells."

According to the news editors, the research concluded: "Our work will shed light on design of chiral anticancer drugs targeting G-quadruplex DNA, and developing telomere and telomerase modulation agents."

For more information on this research see: G-Quadruplex binding enantiomers show chiral selective interactions with human telomere. Nucleic Acids Research, 2014;42(6):3792-3802. Nucleic Acids Research can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Nucleic Acids Research - nar.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting J.S. Wang, Jilin University, Hosp 1, Dept. of Neurosurg, Changchun 130021, Jilin, People's Republic of China. Additional authors for this research include Y. Chen, J.S. Ren, C.Q. Zhao and X.G. Qu (see also Chromosome Structures).

Keywords for this news article include: Asia, Telomere, Changchun, DNA Research, Nanotechnology, Supramolecular, Intranuclear Space, Chromosome Structures, Emerging Technologies, Cell Nucleus Structures, People's Republic of China

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Source: Life Science Weekly