By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Investigators publish new report on Immunization. According to news reporting originating in La Jolla, California, by NewsRx journalists, research stated, "Cell-derived nanoparticles have been garnering increased attention due to their ability to mimic many of the natural properties displayed by their source cells. This top-down engineering approach can be applied toward the development of novel therapeutic strategies owing to the unique interactions enabled through the retention of complex antigenic information."
The news reporters obtained a quote from the research from the University of California, "Herein, we report on the biological functionalization of polymeric nanoparticles with a layer of membrane coating derived from cancer cells. The resulting core shell nanostructures, which carry the full array of cancer cell membrane antigens, offer a robust platform with applicability toward multiple modes of anticancer therapy. We demonstrate that by coupling the particles with an immunological adjuvant, the resulting formulation can be used to promote a tumor-specific immune response for use in vaccine applications."
According to the news reporters, the research concluded: "Moreover, we show that by taking advantage of the inherent homotypic binding phenomenon frequently observed among tumor cells the membrane functionalization allows for a unique cancer targeting strategy that can be utilized for drug delivery applications."
For more information on this research see: Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery. Nano Letters, 2014;14(4):2181-2188. Nano Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Nano Letters - www.pubs.acs.org/journal/nalefd)
Our news correspondents report that additional information may be obtained by contacting R.H. Fang, University of California, Moores Canc Center, La Jolla, CA 92093, United States. Additional authors for this research include C.M.J. Hu, B.T. Luk, W.W. Gao, J.A. Copp, Y.Y. Tai, D.E. O'Connor and L.F. Zhang (see also Immunization).
Keywords for this news article include: Therapy, La Jolla, Oncology, California, Immunization, Nanoparticle, United States, Cell Membrane, Nanotechnology, Cancer Vaccines, Cellular Structures, Drug Delivery Systems, Emerging Technologies, North and Central America
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