By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Polyethylenes. According to news reporting originating in Uttar Pradesh, India, by NewsRx journalists, research stated, "Our main aim in the present investigation was to explore the in vitro and in vivo cancer targeting potential of the doxorubicin (DOX) laden D-alpha-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) tethered surface engineered MWCNTs nanoformulation (DOX/TPGS-MWCNTs) and compare it with pristine MWCNTs and free doxorubicin solution. The developed MWCNTs nanoformulations were extensively characterized by Fourier-transform infrared, Raman spectroscopy, x-ray diffraction, electron microscopy, and in vitro and in vivo studies using MCF-7 cancer cell line."
The news reporters obtained a quote from the research from Central Drug Research Institute, "The entrapment efficiency was determined to be 97.2 +/- 2.50% (DOX/TPGS-MWCNTs) and 92.5 +/- 2.62% (DOX/MWCNTs) ascribed to pi-pi stacking interactions. The developed formulations depicted the sustained release pattern at the lysosomal pH (pH 5.3). The DOX/TPGS-MWCNTs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via endocytosis mechanism. The DOX/TPGS-MWCNTs nanoconjugate depicted the significantly longer survival span (44 days, p< 0.001) than DOX/MWCNTs (23 days), free DOX (18 days) and control group (12 days). The obtained results also support the extended residence time and sustained release profile of the drug loaded surface engineered nanotubes formulations in body as compared to DOX solution."
According to the news reporters, the research concluded: "Overall we can conclude that the developed MWCNTs nanoconjugate have higher cancer targeting potential on tumor bearing Balb/c mice."
For more information on this research see: The cancer targeting potential of D-alpha-tocopheryl polyethylene glycol 1000 succinate tethered multi walled carbon nanotubes. Biomaterials, 2014;35(15):4573-4588. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting N.K. Mehra, CSIR, Cent Drug Res Inst, Div Pharmaceut, Lucknow 226031, Uttar Pradesh, India. Additional authors for this research include A.K. Verma, P.R. Mishra and N.K. Jain (see also Polyethylenes).
Keywords for this news article include: Asia, Antibiotics - Antineoplastics, Pharmaceuticals, India, Drugs, Cancer, Alkenes, Therapy, Oncology, Polyenes, Fullerenes, Succinates, Engineering, Hydrocarbons, Uttar Pradesh, Nanotechnology, Succinic Acids, Carbon Nanotubes, Organic Chemicals, Dicarboxylic Acids, Polyethylene Glycols, Emerging Technologies
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC