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Researchers at Hunan Normal University Describe Findings in Membrane Transport Proteins

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Carrier Proteins. According to news reporting from Changsha, People's Republic of China, by NewsRx journalists, research stated, "Selenocosmia jiafu is a medium-sized theraphosid spider and an attractive source of venom, because it can be bred in captivity and it produces large amounts of venom. We performed reversed-phase high-performance liquid chromatography (RP-HPLC) and matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analyses and showed that S. jiafu venom contains hundreds of peptides with a predominant mass of 3000-4500 Da."

The news correspondents obtained a quote from the research from Hunan Normal University, "Patch clamp analyses indicated that the venom could inhibit voltage-gated Na+, K+ and Ca2+ channels in rat dorsal root ganglion (DRG) neurons. The venom exhibited inhibitory effects on tetrodotoxin-resistant (TTX-R) Na+ currents and T-type Ca2+ currents, suggesting the presence of antagonists to both channel types and providing a valuable tool for the investigation of these channels and for drug development. Intra-abdominal injection of the venom had severe toxic effects on cockroaches and caused death at higher concentrations. The LD50 was 84.24 ?g/g of body weight in the cockroach. However, no visible symptoms or behavioral changes were detected after intraperitoneal injection of the venom into mice even at doses up to 10 mg/kg body weight."

According to the news reporters, the research concluded: "Our results provide a basis for further case-by-case investigations of peptide toxins from this venom."

For more information on this research see: The venom of the spider Selenocosmia jiafu contains various neurotoxins acting on voltage-gated ion channels in rat dorsal root ganglion neurons. Toxins, 2014;6(3):988-1001 (see also Carrier Proteins).

Our news journalists report that additional information may be obtained by contacting Z. Hu, Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China. Additional authors for this research include X. Zhou, J. Chen, C. Tang, Z. Xiao, D. Ying, Z. Liu and S. Liang.

Keywords for this news article include: Asia, Changsha, Ion Channels, Carrier Proteins, Membrane Glycoproteins, People's Republic of China, Membrane Transport Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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