News Column

Research Results from IFIMAV Update Understanding of Phagocytosis

May 28, 2014



By a News Reporter-Staff News Editor at Biotech Week -- New research on Phagocytosis is the subject of a report. According to news originating from Santander, Spain, by NewsRx correspondents, research stated, "The intranasal drug delivery route provides exciting expectations regarding the application of engineered nanomaterials as nano-medicines or drug-delivery vectors into the brain. Among nanomaterials, multiwalled CNTs (MWCNTs) are some of the best candidates for brain cancer therapy since they are well known to go across cellular barriers and display an intrinsic ability to block cancer cell proliferation triggering apoptosis."

Our news journalists obtained a quote from the research from IFIMAV, "This study reveals that microglial cells, the brain macrophages and putative vehicles for MWCNTs into the brain, undergo a dose-dependent cell division arrest and apoptosis when treated with MWCNTs. Moreover, it is shown that MWCNTs severely interfere with both cell migration and phagocytosis in live microglia."

According to the news editors, the research concluded: "These results lead to a re-evaluation of the safety of inhaled airborne CNTs and provide strategic clues of how to biocompatibilize MWCNTs to reduce brain macrophage damage and to develop new nanodrugs."

For more information on this research see: Multiwalled carbon nanotubes hinder microglia function interfering with cell migration and phagocytosis. Advanced Healthcare Materials, 2014;3(3):424-32. (Wiley-Blackwell - www.wiley.com/; Advanced Healthcare Materials - onlinelibrary.wiley.com/journal/10.1002/(ISSN)2192-2659)

The news correspondents report that additional information may be obtained from J.C. Villegas, Departamento de Anatomia y Biologia Celular, Universidad de Cantabria-IFIMAV, 39011, Santander, Spain. Additional authors for this research include L. Alvarez-Montes, L. Rodriguez-Fernandez, J. Gonzalez, R. Valiente and M.L Fanarraga (see also Phagocytosis).

Keywords for this news article include: Spain, Europe, Therapy, Santander, Microglia, Neuroglia, Fullerenes, Nanomaterial, Phagocytosis, Nanotechnology, Carbon Nanotubes, Drug Delivery Systems, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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