News Column

Reports Summarize Leukemia Findings from Department of Urology

May 26, 2014

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Oncology have been published. According to news originating from Weifang, People's Republic of China, by NewsRx correspondents, research stated, "Accumulating data indicate that cancer stem cells play an important role in tumorigenesis and are underlying cause of tumor recurrence and metastasis, specifically in chronic myeloid leukemia (CML). We aim to detect the miRNAs that are correlated with the cancer stem cells in CML to provide theoretical basis for clinical application."

Our news journalists obtained a quote from the research from the Department of Urology, "We first analyzed microRNA expression profiles of CML leukemia patients compared with normal controls by microarray analysis and validated the results by real-time PCR. A single microRNA signature classified CML from normal was detected. We also determined the absolute copy numbers of these three microRNAs in normal adults. The results showed that three microRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 CML patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased microRNAs were significant in clinical analysis. All these results indicated that those three microRNAs could act as a tumor suppressor and their decreased expression might be one of the causes of leukemia."

According to the news editors, the research concluded: "Accordingly, clarifying their regulatory mechanisms might delineate their potentials as drug targets of gene therapy for CML."

For more information on this research see: Studies on microRNAs that are correlated with the cancer stem cells in chronic myeloid leukemia. Molecular and Cellular Biochemistry, 2014;390(1-2):75-84. Molecular and Cellular Biochemistry can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer -; Molecular and Cellular Biochemistry -

The news correspondents report that additional information may be obtained from X.S. Zhu, Weifang Tradit Chinese Med Hosp, Dept. of Urol, Weifang, People's Republic of China. Additional authors for this research include Z.Y. Lin, J. Du, X. Zhou, L.W. Yang and G. Liu (see also Oncology).

Keywords for this news article include: Asia, Biotechnology, Weifang, Oncology, Hematology, Bioengineering, Stem Cell Research, Cancer Gene Therapy, Leukemia Gene Therapy, Chronic Myeloid Leukemia, People's Republic of China

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Source: Cancer Gene Therapy Week

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