News Column

Reports from Lund University Hospital Highlight Recent Findings in Life Science Research

May 27, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Life Science Research is now available. According to news reporting originating in Lund, Sweden, by NewsRx journalists, research stated, "Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta."

The news reporters obtained a quote from the research from Lund University Hospital, "In particular, we investigated whether cell-free Hb affects the release of placental syncytiotrophoblast vesicles (STBMs) and their micro-RNA content. The dual ex-vivo perfusion system was used to perfuse isolated cotyledons from human placenta, with medium alone (control) or supplemented with cell-free Hb. Perfusion medium from the maternal side of the placenta was collected at the end of all perfusion phases. The STBMs were isolated using ultra-centrifugation, at 10,000 x g and 150,000 x g (referred to as 10K and 150K STBMs). The STBMs were characterized using the nanoparticle tracking analysis, identification of surface markers and transmission electron microscopy. RNA was extracted and nine different micro-RNAs, related to hypoxia, PE and Hb synthesis, were selected for analysis by quantitative PCR. All micro-RNAs investigated were present in the STBMs. Mir-517a, mir-141 and mir-517b were down regulated after Hb perfusion in the 10K STBMs. Furthermore, Hb was shown to be carried by the STBMs. This study showed that Hb perfusion can alter the micro-RNA content of released STBMs. Of particular interest is the alteration of two placenta specific micro-RNAs; mir-517a and mir-517b."

According to the news reporters, the research concluded: "We have also seen that STBMs may function as carriers of Hb into the maternal circulation."

For more information on this research see: Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia. Plos One, 2014;9(2):e90020. (Public Library of Science -; Plos One -

Our news correspondents report that additional information may be obtained by contacting T. Cronqvist, Division of Obstetrics and Gynecology, Dept. of Clinical Sciences, Lund University Hospital, Lund University, Lund, Sweden. Additional authors for this research include K. Salje, M. Familari, S. Guller, H. Schneider, C. Gardiner, I.L. Sargent, C.W. Redman, M. Morgelin, B. Akerstrom, M. Gram and S.R Hansson (see also Life Science Research).

Keywords for this news article include: Lund, Sweden, Europe, Life Science Research.

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Source: Life Science Weekly

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