By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Applied Polymer Science. According to news reporting out of Ankara, Turkey, by NewsRx editors, research stated, "The electrospinning of a polymer melt is an interesting process for medical applications because it eliminates the cytotoxic effects of solvents in the electrospinning solution. Wound dressings made from thermoplastic polyurethane (TPU), particularly as a porous structured electrospun membrane, are currently the focus of scientific and commercial interest."
Our news journalists obtained a quote from the research from Hacettepe University, "In this study, we developed a functionalized fibrillar structure as a novel antibacterial wound-dressing material with the melt-electrospinning of TPU. The surface of the fibers was modified with poly(ethylene glycol) (PEG) and silver nanoparticles (nAg's) to improve their wettability and antimicrobial properties. TPU was processed into a porous, fibrous network of beadless fibers in the micrometer range (4.89 +/- 0.94 m). The X-ray photoelectron spectroscopy results and scanning electron microscopy images confirmed the successful incorporation of nAg's onto the surface of the fiber structure. An antibacterial test indicated that the PEG-modified nAg-loaded TPU melt-electrospun structure had excellent antibacterial effects against both a Gram-positive Staphylococcus aureus strain and Gram-negative Escherichia coli compared to unmodified and PEG-modified TPU fiber mats. Moreover, modification with nAg's and PEG increased the water-absorption ability in comparison to unmodified TPU. The cell viability and proliferation on the unmodified and modified TPU fiber mats were investigated with a mouse fibroblast cell line (L929). The results demonstrate that the PEG-modified nAg-loaded TPU mats had no cytotoxic effect on the fibroblast cells."
According to the news editors, the research concluded: "Therefore, the melt-electrospun TPU fiber mats modified with PEG and nAg have the potential to be used as antibacterial, humidity-managing wound dressings."
For more information on this research see: Functionally Modified, Melt-Electrospun Thermoplastic Polyurethane Mats for Wound-Dressing Applications. Journal of Applied Polymer Science, 2014;131(8):167-178. Journal of Applied Polymer Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Applied Polymer Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4628)
Our news journalists report that additional information may be obtained by contacting C. Hacker, Hacettepe University, Div Biochem, Dept. of Chem, TR-06800 Ankara, Turkey. Additional authors for this research include Z. Karahaliloglu, G. Seide, E.B. Denkbas and T. Gries (see also Applied Polymer Science).
Keywords for this news article include: Ankara, Turkey, Eurasia, Applied Polymer Science
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