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Recent Research from Zhejiang University Highlight Findings in Neoplasm Antigens

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Immunology. According to news reporting originating from Hangzhou, People's Republic of China, by NewsRx correspondents, research stated, "The fabrication of staphylococcal protein A (SPA) film on Au nanoparticle (AuNPs)-modified electrode was done for the construction of electrochemical immunosensor. In this work, a highly sensitive electrochemical immunosensor for the detection of a tumor biomarker, carcinoembryonic antigen (CEA) was developed by absorption of anti-CEA antibodies on the SPA-AuNPs modified gold electrode."

Our news editors obtained a quote from the research from Zhejiang University, "Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques were employed in the determination of electrode responses and applicability. Under the optimized condition, the immunosensor displays a good linear response to CEA with a range from 1 pg/ml to 100 ng/ml and a detection limit of 0.1 pg/ml. Furthermore, samples of 1-50 ng/ml CEA in rat serum was detected using the immunosensor and the immunosensor showed acceptable recoveries when the CEA value is within the scope of clinical detection."

According to the news editors, the research concluded: "It can be concluded that the immunosensor provides a promising ultrasensitive immunology strategy for clinical diagnosis."

For more information on this research see: An ultrasensitive electrochemical immunosensor for carcinoembryonic antigen detection based on staphylococcal protein A-Au nanoparticle modified gold electrode. Sensors and Actuators B-Chemical, 2014;197():220-227. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Immunology).

The news editors report that additional information may be obtained by contacting J. Zhou, Zhejiang University, Dept. of Biomed Engn, Biosensor Natl Special Lab, Key Lab Biomed EngnEduc Minist, Hangzhou 310027, Zhejiang, People's Republic of China. Additional authors for this research include L.P. Du, L. Zou, Y.C. Zou, N. Hu and P. Wang.

Keywords for this news article include: Asia, Hangzhou, Chemistry, Immunology, Glycoproteins, Electrochemical, Membrane Proteins, Neoplasm Antigens, Cell Adhesion Molecules, Biological Tumor Markers, Carcinoembryonic Antigen, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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