By a News Reporter-Staff News Editor at Hematology Week -- Researchers detail new data in Cardiovascular Diseases and Conditions. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Nanodiamonds (NDs) have been evaluated for a wide range of biomedical applications. Thus, thorough investigation of the biocompatibility of NDs has become a research priority."
Our news journalists obtained a quote from the research from the East China University of Science and Technology, "Platelets are highly sensitive and are one of the most abundant cell types found in blood. They have a central role in hemostasis and arterial thrombosis. In this study, we aim to investigate the direct and acute effects of carboxylated NDs on platelet function. In this study, pro-coagulant parameters such as platelet aggregability, intracellular Ca2+ flux, mitochondrial transmembrane potential (Delta psi(m)), generation of reactive oxygen species, surface exposure of phosphatidylserine, electron microscopy, cell viability assay and in vivo thromboembolism were analyzed in great detail. Carboxylated NDs evoked significant activation of human platelets. When administered intravenously in mice, NDs were found to induce widespread pulmonary thromboembolism, indicating the remarkable thrombogenic potential of this nanomaterial. Our findings raise concerns regarding the putative biomedical applications of NDs pertaining to diagnostics and therapeutics, and their toxicity and prothrombotic properties should be critically evaluated."
According to the news editors, the research concluded: "Original submitted 15 June 2012; Revised submitted 22 January 2013; Published online 30 April 2013."
For more information on this research see: Nanodiamonds activate blood platelets and induce thromboembolism. Nanomedicine, 2014;9(3):397-412. Nanomedicine can be contacted at: Future Medicine Ltd, Unitec House, 3RD Floor, 2 Albert Place, Finchley Central, London, N3 1QB, England. (Elsevier - www.elsevier.com; Nanomedicine - www.elsevier.com/wps/product/cws_home/703416)
The news correspondents report that additional information may be obtained from W. Tang, E. China University of Science & Technology, Minist Educ, Engn Res Center Biomed Mat, Shanghai 200237, People's Republic of China. Additional authors for this research include Y. Yuan, C.S. Liu, Y.Q. Wu, X. Lu and J.C. Qian (see also Cardiovascular Diseases and Conditions).
Keywords for this news article include: Asia, Shanghai, Hematology, Therapeutics, Thromboembolism, Embolism and Thrombosis, People's Republic of China, Cardiovascular Diseases and Conditions
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