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Recent Reports from Nagoya University Graduate School of Medical Sciences Highlight Findings in Incontinence

May 28, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Gastroenterology. According to news reporting originating from Nagoya, Japan, by NewsRx correspondents, research stated, "To assess the efficacy and safety of a novel cell therapy for male stress urinary incontinence consisting of periurethral injection of autologous adipose-derived regenerative cells, and to determine the 1-year outcomes. A total of 11 male patients with persistent stress urinary incontinence after prostate surgery were included in the study."

Our news editors obtained a quote from the research from the Nagoya University Graduate School of Medical Sciences, "The Celution system was used to isolate adipose-derived regenerative cells from abdominal adipose tissue obtained by liposuction. Subsequently, these regenerative cells, and a mixture of regenerative cells and adipose tissue were transurethrally injected into the rhabdosphincter and submucosal space of the urethra, respectively. The 1-year outcomes were assessed using a 24-h pad test, a validated patient questionnaire, urethral pressure profile, transrectal ultrasonography and magnetic resonance imaging. Stress urinary incontinence improved progressively in eight patients during the 1-year follow up, as determined by a 59.8% decrease in the leakage volume in the 24-h pad test, decreased frequency and amount of incontinence, and improved quality of life. One patient achieved total continence. The mean maximum urethral closing pressure and functional profile length increased from 35.5 to 44.7 cmH?O, and from 20.4 to 26.0 mm, respectively. Magnetic resonance imaging showed the sustained presence of the injected adipose tissue, and enhanced ultrasonography showed a progressive increase in blood flow to the injected area in all patients. No significant adverse events were observed peri-or postoperatively."

According to the news editors, the research concluded: "Periurethral injection of autologous adipose-derived regenerative cells might represent a safe and feasible treatment modality for male stress urinary incontinence."

For more information on this research see: Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients. International Journal of Urology, 2014;21(3):294-300. (Wiley-Blackwell -; International Journal of Urology -

The news editors report that additional information may be obtained by contacting M. Gotoh, Dept. of Urology, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan. Additional authors for this research include T. Yamamoto, M. Kato, T. Majima, K. Toriyama, Y. Kamei, Y. Matsukawa, A. Hirakawa and Y. Funahashi (see also Gastroenterology).

Keywords for this news article include: Asia, Japan, Nagoya, Therapy, Urology, Incontinence, Gastroenterology, Adverse Drug Reaction.

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Source: Biotech Week

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