Ovarian cancer cells spread, or metastasize, by a different method than other cancer cells. Breast cancer cells, for example, break off from a solid tumor and flow through the blood until they arrest in small blood vessels. The cancer cells then penetrate the vessel surface to form a tumor. Because ovarian tumors are in the abdomen, these cancer cells are shed into the surrounding fluid and not distributed through the blood. They must be able to adhere directly to the fatty tissue that lines the gut, called the omentum, to begin forming a tumor. The new study discovered details about how ovarian cancer cells seem to prefer the mechanical properties of this soft tissue (see also
The study was published in a recent advance online edition of the
The research team, led by
"All the behaviors that we associate with breast cancer cells on these more rigid environments are flipped for ovarian cancer cells," Dawson said.
After adhering to these soft surfaces, metastatic ovarian cancer cells became more aggressive. Their proliferation increased and they were less responsive to chemotherapeutics. The ovarian cancer cells were also more motile on soft surfaces, moving nearly twice as fast as on rigid surfaces.
The team also found that less aggressive cells that do not metastasize do not exhibit any of these changes.
The researchers used techniques that haven't been traditionally used in the study of ovarian cancer. They measured the force exerted by the cells by tracking the displacement of beads in the environment around the cells. The researchers found that the metastatic cells increased their traction forces - used to generate motion - by three-fold on soft surfaces, but no such change was present in the less aggressive cells.
"We think the behavior that metastatic ovarian cancer cells exert on these soft surfaces is representative of the mechanical tropism that they have for these softer tissues in the gut," Dawson said.
In future work, the researchers will investigate whether ovarian cancer cells have some natural inclination towards this uniquely more aggressive behavior in softer environments.
"We're trying to find out whether there is some internal programming that leads to this aggressive behavior," Dawson said.
Keywords for this news article include: Biomedical Engineering, Biomedicine, Cancer, Oncology, Bioengineering, Regenerative Medicine,
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