News Column

New Supramolecular Research Findings from University of Amsterdam Described

May 27, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Supramolecular Research. According to news reporting originating from Amsterdam, Netherlands, by NewsRx correspondents, research stated, "This protocol describes how to prepare 2-(2-formylalkyl)-arenecarboxylic acid derivatives, common building blocks for the synthesis of various valuable chemicals (e.g., anti-obesity and Alzheimer's disease treatment pharmaceuticals), by using the fully regioselective hydroformylation of vinyl arene derivatives. This catalytic reaction proceeds cleanly with 100% regioselectivity and chemoselectivity."

Our news editors obtained a quote from the research from the University of Amsterdam, "The procedure is reliably scalable and can be efficiently conducted on a multigram scale. The analytically pure product is easily isolated with a nearly quantitative yield by using a simple acid-base extraction workup and avoids any tedious chromatography. This protocol details the synthesis of a bisphosphite ligand (L1) that is a pivotal element of the catalytic system used, Rh(acac)(CO)(2) with ligand L1, starting from commercial building blocks. The protocol also describes a general procedure for the preparative hydroformylation of vinylarene-2-carboxylic acid derivatives to 2-formylalkylarene products, providing a representative example for the hydroformylation of 2-vinylbenzoic acid (1a) to 2-(3-oxopropane)-benzoic acid (2a). The synthesis of L1 (six chemical reactions) uses 2-nitrophenylhydrazine, 4-benzyloxybenzoylchloride and (S)-binol, and takes 5-7 working days."

According to the news editors, the research concluded: "The actual hydroformylation reaction of each vinyl arene derivative takes similar to 4 h of active effort over a period of 1-3 d."

For more information on this research see: Scalable and chromatography-free synthesis of 2-(2-formylalkyl) arenecarboxylic acid derivatives through the supramolecularly controlled hydroformylation of vinylarene-2-carboxylic acids. Nature Protocols, 2014;9(5):1183-1191. Nature Protocols can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Protocols -

The news editors report that additional information may be obtained by contacting P. Dydio, University of Amsterdam, Vant Hoff Inst Mol Sci, Amsterdam, Netherlands (see also Supramolecular Research).

Keywords for this news article include: Europe, Amsterdam, Netherlands, Nanotechnology, Carboxylic Acids, Organic Chemicals, Emerging Technologies, Supramolecular Research

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Source: Life Science Weekly