News Column

New Nanoparticles Study Findings Have Been Reported by K.M. Gregorio-Jauregui and Colleagues

May 27, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting originating from Coahuila, Mexico, by NewsRx correspondents, research stated, "The interaction between influenza virus hemagglutinins and host cell with terminal sialic acid linked receptors, SA-alpha-2,6-Gal for human strains is important to obtain insights into this infectious disease. Sambucus nigra lectin has high affinity for SA-alpha-2,6-Gal receptors."

Our news editors obtained a quote from the research, "The goals of this work were: to extract the SA-alpha-2,6-Gal receptors from porcine airways; to perform receptors immobilization and study their storage stability; and to determine some parameters of interaction between the receptor and S. nigra lectin. The receptor isolation was monitored by means of bound sialic acid (BSAc) detection. A major band of protein at 66.7 kDa was clearly visible in SDS-PAGE assay. Eighty-one percent of isolated glycoproteins were immobilized on magnetic nanoparticles. The kinetics of BSAc storage stability at 4 A degrees C was approximated as the first order reaction with kinetic constant and half-life estimated as 0.062 day(-1) and 11.2 days, respectively."

According to the news editors, the research concluded: "The dissociation constant (K (d)) calculated from Scatchard's plot was 2.47 x 10(-7) M, and the receptor concentration was equal to 7.92 x 10(-5) M. Procedure for N-SA-alpha-2,6-Gal -receptors extraction based on their affinity to S. nigra lectin with magnetic nanoparticles, and their immobilization in active form, was not described previously, and may have wide application in designing biosensors or virus removal from areas or contaminated samples."

For more information on this research see: Extraction and Immobilization of SA-alpha-2,6-Gal Receptors on Magnetic Nanoparticles to Study Receptor Stability and Interaction with Sambucus nigra Lectin. Applied Biochemistry and Biotechnology, 2014;172(8):3721-3735. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)

The news editors report that additional information may be obtained by contacting K.M. Gregorio-Jauregui, Center Invest Quim Aplicada, Dept. of Proc Polimerizac, Saltillo 25294, Coahuila, Mexico. Additional authors for this research include S.A. Carrizalez-Alvarez, J.E. Rivera-Salinas, H. Saade, J.L. Martinez, R.G. Lopez, E.P. Segura and A. Ilyina (see also Nanoparticles).

Keywords for this news article include: Mexico, Coahuila, Nanotechnology, Emerging Technologies, North and Central America

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Source: Life Science Weekly