By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nanoparticles. According to news originating from Inchon, South Korea, by NewsRx correspondents, research stated, "Nanoparticle-based diagnosis therapy integrative systems represent an emerging approach to cancer treatment. However, the diagnostic sensitivity, treatment efficacy, and bioavailability of nanoparticles as well as the heterogeneity and drug resistance of tumors pose tremendous challenges for clinical implementation."
Our news journalists obtained a quote from the research from Inha University, "We herein report on the fabrication of tumor pH-sensitive magnetic nanogrenades (termed PMNs) composed of self-assembled iron oxide nanoparticles and pH-responsive ligands. These PMNs can readily target tumors via surface-charge switching triggered by the acidic tumor microenvironment, and are further disassembled into a highly active state in acidic subcellular compartments that 'turns on' MR contrast, fluorescence and photodynamic therapeutic activity. We successfully visualized small tumors implanted in mice via unique pH-responsive T1MR contrast and fluorescence, demonstrating early stage diagnosis of tumors without using any targeting agents. Furthermore, pH-triggered generation of singlet oxygen enabled pH-dependent photodynamic therapy to selectively kill cancer cells."
According to the news editors, the research concluded: "In particular, we demonstrated the superior therapeutic efficacy of PMNs in highly heterogeneous drug-resistant tumors, showing a great potential for clinical applications."
For more information on this research see: Multifunctional Tumor pH-Sensitive Self-Assembled Nanoparticles for Bimodal Imaging and Treatment of Resistant Heterogeneous Tumors. Journal of the American Chemical Society, 2014;136(15):5647-5655. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
The news correspondents report that additional information may be obtained from D. Ling, Inha University, Dept. of Radiol, Coll Med, Inchon 420751, South Korea. Additional authors for this research include W. Park, S.J. Park, Y. Lu, K.S. Kim, M.J. Hackett, B.H. Kim, H. Yim, Y.S. Jeon, K. Na and T. Hyeon (see also Nanoparticles).
Keywords for this news article include: Asia, Inchon, Therapy, South Korea, Nanotechnology, Emerging Technologies
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