By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanoparticles. According to news reporting from Catania, Italy, by NewsRx journalists, research stated, "The nasal route has received a great deal of attention as a convenient and reliable method for the brain target on administration of drugs. When drugs are loaded into nanoparticles (NPs) the interaction with mucosa transports directly into the brain, skipping the blood-brain barrier and achieving rapid cerebrospinal fluid levels."
The news correspondents obtained a quote from the research from the University of Catania, "Poly-lactic acid (PLA), poly-lactic-co-glycolic acid (PLGA), and chitosan (CS) were chosen to prepare NPs. After optimization of CS nanocarriers, our goal was to evaluate the different type of NPs uptake into olfactory ensheathing cells (OECs). We then correlated obtained biological data to zeta potential measurements of cells treated with NPs. Rodhamine-loaded NPs were used to study the uptake of OECs carried out by confocal microscopy at different times (1, 2, and 4 h). Our results showed that uptake of rodhamine-NPs by OECs was time dependent and it was influenced by the carrier charge. Confocal imaging of OECs demonstrated that NPPLGA showed a higher increase in uptake compared with NPPLA and NPCS after 1 h and it increased at 2-4 h. Zeta potential values of treated cells were more amplified with respect to untreated cells."
According to the news reporters, the research concluded: "The highest values were showed by unloaded NPPLGA, confirming microscopy data."
For more information on this research see: Nose-to-brain delivery: evaluation of polymeric nanoparticles on olfactory ensheathing cells uptake. Journal of Pharmaceutical Sciences, 2014;103(2):628-35. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
Our news journalists report that additional information may be obtained by contacting T. Musumeci, Dept. of Drug Science, University of Catania, Catania, 6-95125, Italy. Additional authors for this research include R. Pellitteri, M. Spatuzza and G. Puglisi (see also Nanoparticles).
Keywords for this news article include: Italy, Europe, Catania, Nanotechnology, Emerging Technologies.
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