News Column

New Findings on Cardiology from Massachusetts Institute of Technology Summarized

May 26, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Cardiology. According to news reporting originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "Patients with chest pain account for 10% of US emergency room visits according to data from the Center for Disease Control and Prevention (2013). For triage of these patients, cardiac biomarkers troponin I and T are endorsed as standard indicators for acute myocardial infarction (AMI, or heart attack)."

Our news editors obtained a quote from the research from the Massachusetts Institute of Technology, "Thus, there is significant interest in developing a rapid, point-of-care (POC) device for troponin detection. In this work, a rapid, quantitative, and label-free assay, which is specific for cardiac troponin T (cTnT) detection, using fluorescent single-walled carbon nanotubes (SWCNTs), is demonstrated. Chitosan-wrapped carbon nanotubes are cross-linked to form a thin gel that is further functionalized with nitrilotriacetic acid (NTA) moieties. Upon chelation of Ni(2+) , the Ni(2+) -NTA group binds to a hexa-histidine-modified troponin antibody, which specifically recognizes the target protein, troponin T. As the troponin T binds to the antibody, the local environment of the sensor changes, allowing direct troponin detection through intensity changes in SWCNT bandgap fluorescence. This platform represents the first near-infrared SWCNT sensor array for cTnT detection. Detection can be completed within 5 min, demonstrating a linear response to cTnT concentration and an experimental detection limit of 100 ng mL(-1) (2.5 nm). This platform provides a promising new tool for POC AMI detection in the future."

According to the news editors, the research concluded: "Moreover, the work presents two new methods of quantifying the number of amines and carboxylic groups, respectively, in a carbon hydrogel matrices."

For more information on this research see: A rapid, direct, quantitative, and label-free detector of cardiac biomarker troponin T using near-infrared fluorescent single-walled carbon nanotube sensors. Advanced Healthcare Materials, 2014;3(3):412-23. (Wiley-Blackwell -; Advanced Healthcare Materials -

The news editors report that additional information may be obtained by contacting J. Zhang, Dept. of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States. Additional authors for this research include S. Kruss, A.J. Hilmer, S. Shimizu, Z. Schmois, F. De La Cruz, P.W. Barone, N.F. Reuel, D.A. Heller and M.S Strano (see also Cardiology).

Keywords for this news article include: Antibodies, Cambridge, Cardiology, Fullerenes, Immunology, Massachusetts, United States, Blood Proteins, Nanotechnology, Immunoglobulins, Emerging Technologies, North and Central America, Single Walled Carbon Nanotubes.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cardiovascular Week

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