News Column

New Findings from Institute of Chemical Technology Yields New Data on Enzymes and Coenzymes

May 27, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Enzymes and Coenzymes is now available. According to news reporting originating in Mumbai, India, by NewsRx journalists, research stated, "The present study is aimed at enhanced production of a fibrinolytic enzyme from Bacillus sphaericus MTCC 3672 under ultrasonic stimulation. Various process parameters viz; irradiation at different growth phases, ultrasonication power, irradiation duration, duty cycle and multiple irradiation were studied for enhancement of fibrinolytic enzyme productivity."

The news reporters obtained a quote from the research from the Institute of Chemical Technology, "The optimum conditions were found as follows, irradiation of ultrasonic waves to fermentation broth at 12 h of growth phase with 25 kHz frequency, 160 W ultrasound power, 20% duty cycle for 5 min. The productivity of fibrinolytic enzyme was increased 1.82-fold from 110 to 201 U/mL compared with the non sonicated control fermentation. Drop in glucose concentration from 0.41% to 0.12% w/v in ultrasonicated batch implies that, ultrasonication increases the cell permeability, improves substrate intake and progresses metabolism of microbial cell. Microscopic images before and after ultrasonic stimulation clearly signifies the impact of duty cycle on decreasing biomass concentration. However, environmental scanning electron micrograph does not show any cell lysis at optimum ultrasonic irradiation."

According to the news reporters, the research concluded: "Offshoots of our results will contribute to fulfill the demand of enhancement of microbial therapeutic enzyme productivity, through ultrasonication stimulation."

For more information on this research see: Ultrasound stimulated production of a fibrinolytic enzyme. Ultrasonics Sonochemistry, 2014;21(1):182-8. (Elsevier -; Ultrasonics Sonochemistry -

Our news correspondents report that additional information may be obtained by contacting D.N. Avhad, Dept. of Chemical Engineering, Institute of Chemical Technology, Matunga (E), Mumbai 400019, India (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, India, Mumbai, Enzymes and Coenzymes.

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Source: Life Science Weekly