By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Terpenes have been published. According to news originating from Lille, France, by NewsRx correspondents, research stated, "Three selective CB2 cannabinoid receptor ligands have recently been discovered to be promising anti-inflammatory agents but their low water solubility hinder their per os administration. The popularity of the cyclodextrins, from a pharmaceutical standpoint lies on their ability to interact with poorly water-soluble drugs and improve their solubility."
Our news journalists obtained a quote from the research from the University of Lille, "Herein, three experimental approaches for calculating the stability constant of complexes between the selective CB2 ligands and either the beta-CD or the HP-beta-CD, were tested: nuclear magnetic resonance, micellar electrokinetic chromatography and high performance liquid chromatography in reversed phase. In NMR studies the calculated K values were relatively high and were between 1486 and 3571 M-1 with beta-CD. With HP-beta-CD they were between 1203 and 2650 M-1. Concerning the two others techniques the K values were found lower. In MECK studies with beta-CD they were between 308 and 792 M-1 and with HP-beta-CD between 124 and 764 M-1. Finally in RP-HPLC studies with beta-CD, they were between 539 and 1144 M-1 and with HP-beta-CD between 196 and 396 M-1. These calculated constants suggest that a complexation phenomenon occurs."
According to the news editors, the research concluded: "A model for inclusion of one of the CB2 ligands in the beta-CD was then proposed from molecular modeling studies."
For more information on this research see: NMR studies of interactions of new CB2 cannabinoid receptor ligands with cyclodextrins hosts. Correlation with micellar electrokinetic chromatography and reversed phase high performance liquid chromatography. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014;78(1-4):265-274. Journal of Inclusion Phenomena and Macrocyclic Chemistry can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Inclusion Phenomena and Macrocyclic Chemistry - www.springerlink.com/content/0923-0750/)
The news correspondents report that additional information may be obtained from N. Azaroual, University of Lille, Lab Chim Analyt, Fac Sci Pharmaceut & Biol, F-59006 Lille, France. Additional authors for this research include J. El Bakali, D. Le Broc, C. Deghaye, A. Farce, P. Chavatte, R. Millet, C. Vaccher and E. Lipka-Belloli (see also Terpenes).
Keywords for this news article include: Lille, France, Europe, Terpenes, CB2 Receptor, Nanotechnology, Electrokinetics, Membrane Proteins, Imaging Technology, Cannabinoid Receptors, Emerging Technologies, G-Protein-Coupled Receptors, High-Performance Liquid Chromatography
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