News Column

Findings from University of Jena Provides New Data on Nanocapsules

May 30, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Nanocapsules have been published. According to news reporting out of Jena, Germany, by NewsRx editors, research stated, "Bacterial-mediated diseases are a major healthcare concern worldwide due to the rapid spread of antibiotic-resistant bacteria. One strategy to manage the bacterial infections while avoiding the emergence of resistant strains implies specific targeting and disruption of bacteria membranes."

Our news journalists obtained a quote from the research from the University of Jena, "This work evaluates the potential of nanostructured biopolymer derivatives, nanocapsules (NCs), to disrupt the bacteria cell walls and effectively kill planktonic microorganisms. Two biopolymers, chitosan and cellulose, were chemically modified to synthesize derivatives with improved cationic character (thiolated chitosan and aminocellulose) prior to their processing into nanocapsules via a one-step sonochemical process. The interactions of NCs, displaying an average size of around 250 nm, with bacteria membrane were evaluated using two membrane models: Langmuir monolayers and liposome bilayers composed of a L-alpha-phosphatidylglycerol phospholipid extracted from Escherichia coli. NCs possessed improved membrane disturbing capacity in comparison to the nonprocessed biopolymer derivatives, by drastically increasing the monolayer fluidity and inducing more than 50% leakage of a dye inserted in the bilayered liposomes. In addition, membrane disturbance was directly proportional to the NCs cationic charge. Whereas evidence showed that thiolated chitosan and aminocellulose interacted with the bacteria membrane through a 'carpet model', the NCs were found to induce larger surface defects and high local perturbance through a 'detergent model."

According to the news editors, the research concluded: "Importantly, the degree of disruption caused by the biopolymer derivatives and NCs correlated well with the antimicrobial capacity against Escherichia coil, selectively killing bacteria cells without imparting toxicity to human fibroblasts."

For more information on this research see: Sonochemically Processed Cationic Nanocapsules: Efficient Antimicrobials with Membrane Disturbing Capacity. Biomacromolecules, 2014;15(4):1365-1374. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Biomacromolecules -

Our news journalists report that additional information may be obtained by contacting M.M. Fernandes, University of Jena, Inst Organ Chem & Macromol Chem, Center Excellence Polysaccharide Res, D-07743 Jena, Germany. Additional authors for this research include A. Francesko, J. Torrent-Burgues, F.J. Carrion-Fite, T. Heinze and T. Tzanov (see also Nanocapsules).

Keywords for this news article include: Jena, Europe, Germany, Nanotechnology, Emerging Technologies

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Source: Health & Medicine Week

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