News Column

Data on Tissue Engineering Described by Researchers at University of California

May 30, 2014

By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Investigators publish new report on Biomedicine and Biomedical Engineering. According to news reporting from Los Angeles, California, by NewsRx journalists, research stated, "We examined whether expediting angiogenesis in porous polycaprolactone (PCL) scaffolds could reduce hypoxia and consequently improve the survival of transplanted enteric cells. To accelerate angiogenesis, we delivered vascular endothelial growth factor (VEGF) using PCL scaffolds with surface crosslinked heparin."

The news correspondents obtained a quote from the research from the University of California, "The fabrication and characterization of scaffolds has been reported in our previous study. Enteric cells, isolated from intestinal tissue of neonatal mice and expanded in vitro for 10?days, exhibited high expression levels for contractile protein ?-smooth muscle actin and desmin. The cultured enteric cells were seeded in scaffolds and were implanted subcutaneously in immunodeficient mice for 7 and 14?days. At day 7, the heparin-modified PCL scaffolds with VEGF exhibited significantly increased angiogenesis and engraftment of enteric cells, with a simultaneous reduction in hypoxia. At day 14, the blood vessels grew across the entire thickness of the scaffold and resulted in a significantly diminished hypoxic environment; however, the transplanted cell density did not increase further."

According to the news reporters, the research concluded: "The enhancement of angiogenesis reduced cellular hypoxia and improved the engraftment of enteric cells."

For more information on this research see: Enhancing angiogenesis alleviates hypoxia and improves engraftment of enteric cells in polycaprolactone scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 2013;7(12):925-33. (Wiley-Blackwell -; Journal of Tissue Engineering and Regenerative Medicine -

Our news journalists report that additional information may be obtained by contacting S. Singh, Dept. of Bioengineering, University of California, Los Angeles, CA, United States. Additional authors for this research include B.M. Wu and J.C Dunn (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Biomedicine and Biomedical Engineering, California, Los Angeles, United States, North and Central America.

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Source: Angiogenesis Weekly