News Column

Data on Apoptosis Described by Researchers at Southeast University

May 30, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Apoptosis. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "To explore the effect of folic acid-modified magnetic nanoparticles (FA-MNPs) combined with a 100 Hz extremely low-frequency electromagnetic field (ELF-EMF) on the apoptosis of liver cancer BEL-7402 cells. MNPs (20 nm) were prepared by coprecipitation, and then folic acid was coated onto MNPs to prepare FA-MNPs."

The news correspondents obtained a quote from the research from Southeast University, "BEL-7402 cells and HL7702 cells were selected as liver cancer cells and normal liver cells, respectively. The ELF-EMF was generated from a solenoid coil. Cellular uptake of NPs was determined by inductively coupled plasma atomic emission spectroscopy. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to evaluate cell inhibition. Apoptosis was analyzed by flow cytometry. Statistical analyses were performed using two-way analysis of variance. FA-MNPs combined with a 100 Hz magnetic field significantly inhibited cell -proliferation and induced higher apoptosis compared to either the ELF-EMF alone or FA-MNPs alone. FA-MNPs showed a better apoptosis effect and higher iron uptake in BEL-7402 cells compared to in HL7702 cells. On the basis of the ELF-EMF, higher doses of FA-MNPs brought higher apoptosis and higher iron uptake in either BEL-7402 cells or HL7702 cells."

According to the news reporters, the research concluded: "These results suggest that FA-MNPs may induce apoptosis in a cellular iron uptake-dependent manner when combined with an ELF-EMF in BEL-7402 cells."

For more information on this research see: Apoptosis selectively induced in BEL-7402 cells by folic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field. International Journal of Nanomedicine, 2014;9():2043-2050. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Apoptosis).

Our news journalists report that additional information may be obtained by contacting J. Wen, Southeast Univ, Sch Med, Zhongda Hosp, Dept. of Hematol, Nanjing 210029, Jiangsu, People's Republic of China. Additional authors for this research include S.L. Jiang, Z.Q. Chen, W. Zhao, Y.X. Yi, R.L. Yang and B.A. Chen.

Keywords for this news article include: Asia, Jiangsu, Apoptosis, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China

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Source: Health & Medicine Week

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