News Column

Data from Trinity College Provide New Insights into Vaccines

May 26, 2014

By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Immunization have been published. According to news originating from Dublin, Ireland, by NewsRx correspondents, research stated, "Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials."

Our news journalists obtained a quote from the research from Trinity College, "To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies."

According to the news editors, the research concluded: "These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus."

For more information on this research see: Targeted Nasal Vaccination Provides Antibody-Independent Protection Against Staphylococcus aureus. Journal of Infectious Diseases, 2014;209(9):1479-1484. Journal of Infectious Diseases can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA. (Oxford University Press -; Journal of Infectious Diseases -

The news correspondents report that additional information may be obtained from K. Misstear, Trinity College Dublin, Center Res Adapt Nanostruct & Nanodevices, Dublin 2, Ireland. Additional authors for this research include E.A. McNeela, A.G.Murphy, J.A. Geoghegan, K.M. O'Keeffe, J. Fox, K. Chan, S. Heuking, N. Collin, T.J. Foster, R.M. McLoughlin and E.C. Lavelle (see also Immunization).

Keywords for this news article include: Antibodies, Dublin, Europe, Ireland, Bacillales, Immunology, Vaccination, Immunization, Blood Proteins, Immunoglobulins, Medical Devices, Staphylococcaceae, Pre-Trial Research, Biological Products, Gram-Positive Cocci, Vaccine Development, Staphylococcus aureus, Gram-Positive Bacteria, Endospore-Forming Bacteria

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Clinical Trials Week

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