"Since the discovery of the first antibiotic, penicillin, in 1928, bacteria have become smarter and have developed resistance to many drugs," says Luk, an expert in bio-organic chemistry, nanomaterials and chemical biology. "They've done this by altering their genetic make-up; transferring drug-resistant genes between one another; and creating biofilms, which are multicellular communities where bacteria can be a thousand-fold more resistant to antibiotics."
In response, Luk's team has developed a class of chemical agents that does not kill bacteria but, rather, changes their multicellular behaviors. These agents are called disaccharide derivatives, and they mimic a class of natural molecules known as rhamnolipids, which are produced and secreted by the bacterium itself.
Keywords for this news article include: Chemicals, Chemistry,
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