The news reporters obtained a quote from the research, "Because of the complex nature of faeces, an appropriate extraction and purification procedure was developed. To this extent, a Plackett-Burman experimental design was successfully applied to determine the key conditions for optimal extraction of glucocorticoids from faeces. The targeted analysis, including natural and synthetic glucocorticoids, was successfully validated according to CD 2002/657/EC. Decision limits and detection capabilities for prednisolone, prednisone, methylprednisolone and the metabolites 20 alpha-dihydroprednisolone and 20 beta-dihydroprednisolone ranged, respectively, from 0.15 to 2.95 mu g kg(-1) and from 0.40 to 5.20 mu g kg(-1). Limits of detection and limits of quantification for the natural glucocorticoids dihydrocortisone, cortisol and cortisone ranged, respectively, from 0.55 to 2.10 mu g kg(-1) and from 0.70 to 5.00 mu g kg(-1)."
According to the news reporters, the research concluded: "The stability study of glucocorticoids in faecal matrix demonstrated that lyophilising the faeces, storage at -80 degrees C, and aerobic conditions were optimal for preservation and able to significantly (p < 0.05) limit degradation up to 10 weeks."
For more information on this research see: Development and validation of a high-resolution mass-spectrometry-based method to study the long-term stability of natural and synthetic glucocorticoids in faeces.
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