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Investigators at Shahid-Beheshti University Detail Findings in Nanoparticles

May 23, 2014

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Nanoparticles have been published. According to news reporting originating from Tehran, Iran, by NewsRx correspondents, research stated, "The coextraction of acidic and basic drugs from different samples is a considerable and disputable concept in sample preparation strategies. In this study, for the first time, simultaneous extraction of acidic and basic drugs with magnetic nanoparticles based dispersive micro-solid phase extraction followed by high performance liquid chromatography-ultraviolet detection was introduced."

Our news editors obtained a quote from the research from Shahid-Beheshti University, "Cetyltrimethyl ammonium bromide-coated Fe3O4@decanoic acid as an efficient sorbent was successfully applied to adsorb diclofenac (DIC) as an acidic and diphenhydramine (DPH) as a basic model compound. First, appropriate amount of synthetic Fe3O4@decanoic acid nanoparticles was added to aqueous solution of drugs. After adjusting the pH of the solution, cetyltrimethyl ammonium bromide (CAB) was added to the mixture being stirred at a constant rate. After the adsorption of drugs and decantation of supernatant with a magnetic field, the sorbent was eluted with methanol by fierce vortex. The parameters affecting the extraction efficiency were optimized and obtained as: pH of the sample = 9, concentration of CTAB = 0.2 mmol L-1, amount of sorbent = 10 mg, extraction time = 5 min, no salt addition to sample, type and volume of the eluent = 50 111 methanol, and desorption time = 1 min. Under the optimum conditions detection limits and linear dynamic ranges were achieved in the range of 1.8-3.0, 5-1500 1 mu L-1 for DPH and 1.5-3.5, 5-1500 mu g L-1 for DIC, respectively. The percent of extraction recovery and relative standard deviations (n =5) were in the range of 47.3 - 60, 5.2 - 9.0 for DPH and 64 - 76.7, 5.1 - 5.8 for DIC, respectively."

According to the news editors, the research concluded: "Ultimately, the applicability of the method was successfully confirmed by the extraction and determination of DIC and DPH in human urine, plasma and waste water samples in the range of microgram per liter and satisfactory results were obtained."

For more information on this research see: Magnetic nanoparticles based dispersive micro-solid-phase extraction as a novel technique for coextraction of acidic and basic drugs from biological fluids and waste water. Journal of Chromatography A, 2014;1338():1-8. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier -; Journal of Chromatography A -

The news editors report that additional information may be obtained by contacting A.A. Asgharinezhad, Shahid Beheshti Univ, Fac Chem, GC, Tehran, Iran. Additional authors for this research include N. Mollazadeh, H. Ebrahimzadeh, F. Mirbabaei and N. Shekari (see also Nanoparticles).

Keywords for this news article include: Iran, Asia, Tehran, Nanotechnology, Emerging Technologies, Magnetic Nanoparticles

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Source: Science Letter

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